Results 161 to 170 of about 8,095,394 (310)

Mechanical Engineering 2019 Annual Report 

, 2019
A comprehensive look at the Virginia Tech Department of Mechanical Engineering and its accomplishments in ...

core  

Mechanical Response and Energy Absorption of Bio-Inspired Auxetic Hybrid Tubular Metamaterials. [PDF]

Biomimetics (Basel)
Huo S, Xia F, Xu S, Gao Z, Ruan D.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

On the damping performance and mechanical response of additive-manufactured and thermo-mechanical processed alsimg alloy

Recent advancements in additive manufacturing (AM) fuel efforts for expanding the design envelopes for components obtained via this technology through continuous improvement in mechanical behavior.
Yapici, Guney Guven, Radi, Amin, Isil, Canay   +2 more
core   +1 more source

Non-Monotonic Mechanical Response and Multiscale Damage Evolution of Argillaceous Siltstone Under Wet-Dry Cycles. [PDF]

Materials (Basel)
He Z, Zhang D, Xu G, Zhang N, Zhang H.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanical Response and Low-Order Wave Propagation of Curved-Rod Compression-Torsion Coupled Metamaterials. [PDF]

Materials (Basel)
Gao W, Zhu J.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Thermo-mechanical response of layered perlite beams under transient thermal loading. [PDF]

Sci Rep
Szymczak-Graczyk A, Korentz J, Markiv T, Garbowski T.   +3 more
europepmc   +1 more source