Results 141 to 150 of about 8,095,394 (310)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Tunable Mechanical Response of Self-Assembled Nanoparticle Superlattices
Self-assembled nanoparticle superlattices (NPSLs) are an emergent class of self-architected nanocomposite materials that possess promising properties arising from precise nanoparticle ordering.
Macfarlane, Robert J. +6 more
core +1 more source
, 2021 The conditions to which fiber reinforced plastics (FRPs) are exposed in state of the art applications are becoming more extreme, for example in the offshore oil and gas industry.
PINI T +4 more
core
Mechanical Responses of Pipeline Laid on Cross Slope
Shiyou jixieLandslide is one of the common geological hazards that threaten the operation of oil and gas pipelines.Pipelines laid on cross slopes are most susceptible to landslide and damage.It is extremely important to understand the mechanical responses of buried ...
Han Xuelong +6 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Data encryption using chaotic mechanical system vibration response signals
, 2021 The aim of the project is to establish the chaotic mechanical system by using an additional cubic spring stiffness and a fractional derivative term in a solid-spring damper system. When an external sinusoidal force is added to the system, the system will
Jr, Joseph Leonard Sebastian
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Journal of the American Society of Mechanical Engineers.
Mode of access ...
American Society of Mechanical Engineers.
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source