Results 121 to 130 of about 2,329,116 (298)

Experimental Study on the Influence of Permeation Deformation of Limestone with Different Moisture Contents in Deep-Water Environments

Applied Sciences
This study deeply explores the permeation deformation mechanism of limestone cores in deep-water environments. Through a customized test device, the mechanical responses of deep-water rocks under different moisture content conditions are simulated.
Chunyao Hou, Heng Cheng, Dawen Tan, Yanan Lei, Chenfang Jiang, Yuntian Zhao, Jingjie Tian   +6 more
doaj   +1 more source

The meaning of mechanically produced responses

Australian Journal of Physiotherapy, 1994
The precise source and cause of mechanically evoked sensory and motor responses can sometimes be surprisingly difficult to identify. Accurate interpretation of these responses may be confounded by peripheral as well as central nervous system mechanisms.
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sensitivity Study on Parameters of Buried Steel Pipe Under Lateral Landslide Actions

Shiyou jixie
In order to clarify the parameter sensitivity of pipelines under lateral landslide actions,finite element simulation was conducted to understand the variation of pipeline displacement and axial strain under different landslide,pipeline and soil ...
Han Jianhong, He Peng, Sun Mingyuan, Liu Peng, Wang Shaofeng, Ai Xinyu, Li Yuxing   +6 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Response Time of Queueing Mechanisms

Symmetry
We study response time, a key performance characteristic of queueing mechanisms. The studied model incorporates both active and passive queue management, arbitrary service time distribution, as well as a complex model of arrivals. Therefore, the obtained formulas can be used to calculate the response time of many real queueing mechanisms with different
Andrzej Chydzinski, Blazej Adamczyk
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mechanical response mechanism and temporary support for unsupported roof area in coal roadway excavation

矿业科学学报
This study investigates the mechanical response mechanism and temporary support method of surrounding rock in coal mines under varying unsupported roof distances, with 9103 transportation roadway of Wangzhuang coal mine taken as a case study.
HAO Wenhua, WANG Fangtian, WU Peilin, YIN Zhihua, TANG Tiankuo, LIU Chao, WU Yu   +6 more
doaj   +1 more source