Results 171 to 180 of about 2,305,322 (279)
Experimental dataset on the thermo-mechanical response of an energy piled wall section. [PDF]
Data BriefVillegas L, Fuentes R, Narsilio GA.
europepmc +1 more source
[Mechanism of immune response].
Mikrobiyoloji bulteni, 1983 The mechanism of immune response is not yet very well understood. In the formation of immune response the macrophage, B and T lymphocytes are effective. In the interaction of these cells the physical and soluble secretory factor of the macrophages and T cells induce the differentiation and proliferation of the T and B cells.
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Modelling of Mechanical Response of Weldlines in Injection-Moulded Short Fibre-Reinforced Polymer Components. [PDF]
Polymers (Basel)Nabergoj M, Urevc J, Halilovič M.
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Peripheral heterochromatin tethering is required for chromatin-based nuclear mechanical response. [PDF]
Nucleic Acids ResAttar AG +4 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Mechanical response and energy dissipation law of double-fractured sandstone under dynamic load. [PDF]
Sci RepZhang Q, Xu X, Wu L, Li J, Shi Q, Tan D.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Investigation on failure mechanism and mechanical response of layered rocks based on AE monitoring and 3D numerical simulation. [PDF]
Sci RepLiu H, Zuo J, Lei B.
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