Results 101 to 110 of about 14,667,599 (290)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Addendum to A Blueprint for Ocean Energy Development 2010-2015 [PDF]

OWET convened the second annual OWET Developersʼ Summit on August 2, 2011 in Portland, Oregon. The Summit brought together participants, both new and those who had attended the first OWET Developersʼ Summit 2010, to review the Blueprint for Ocean Energy ...
Oregon Wave Energy Trust
core   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An optimization technique based on mechanical specific energy concept to improve drilling efficiency: a case study

Записки Горного института
For years attempts have been made in the drilling industry to increase the drilling efficiency and decrease the associated costs. The drilling efficiency can be evaluated by comparing applied energy, i.e., mechanical specific energy, with rock strength ...
Sajjad Khoshro, Seyyed Shahab Tabatabaee Moradi   +1 more
doaj  

Mechanical properties and deformation mechanism of laser melting octagonal double pyramid and Kelvin hybrid lattice structure

Journal of Aeronautical Materials
Due to their excellent mechanical properties，dot matrix structures show a broad application prospect for spacecraft lightweight structures and cushioning energy absorbing devices.
YU Jingui, ZHU Yao, ZHANG Qiaoxin
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Energy storage systems for space applications

Publisher Copyright: © 2025 The AuthorsAs resource depletion looms and space technology advances, space exploration prospects are growing. To ensure a sustainable and efficient transition through inhospitable space and towards lunar and Martian outposts,
Santasalo-Aarnio, Annukka, Sharma, Kneev
core   +1 more source

Numerical Simulation on Rock-breaking and Temperature Characteristics of Sawtooth PDC Cutter

Shiyou jixie
Most of the researches on bionic teeth focus on the wave tooth shape, and there are few reports on the rock-breaking properties of sawtooth cutters.Based on plasto elasticity and Drucker-Prager rock failure criteria, a finite element model of interaction
Wu Zebing, Yuan Ruofei, Zhang Wenxi, He Xiaolin, Liu Jiale   +4 more
doaj  

Vibration monitoring at drill-bit and its correlation with downhole mechanical specific energy (MSE)

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Drill-bit vibrations are a part of rock fracturing and breaking in the drilling process, are potentially harmful to equipment, yet provide valuable insights about drilling dynamics and formation properties.
Manzoor Ahmad, Mao Sheng, Zhe Huang, Shimeng Hu, Shouceng Tian, Gensheng Li   +5 more
doaj   +1 more source

The Importance of Molecular Structure for Textural and Physicochemical Properties of Extruded Wheat Flour

Foods
This study elucidated the mechanistic interplay between the extrusion parameters (temperature and screw speed), starch molecular architecture (chain-length distribution), and key physicochemical properties of wheat flour extrudates.
Yuan Chai, Ruibin Wang, Bo Zhang, Yonglu Tang, Chaosu Li, Boli Guo, Ming Li   +6 more
doaj   +1 more source