Results 81 to 90 of about 1,500,948 (299)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Research on mechanical specific energy model and parameters optimization of deep coal seam drilling considering jet-screw interaction

Meikuang Anquan
The Linxing Block on the eastern margin of Ordos Basin contains abundant coalbed methane resources. However, drilling operations in this area face challenges such as low efficiency and high technical difficulty due to factors including deep burial depth ...
Guangyu XIE, Jia HE, Xiangwei KONG, Hongxing XU, Min XU, Yu TANG, Zhenghao LI   +6 more
doaj   +1 more source

Specific Mechanical Energy and Thermal Degradation of Poly(lactic acid) and Poly(caprolactone)/Date Pits Composites

International Journal of Polymer Science, 2018
The compatibility of date pits (DP) with polylactic acid (PLA) or polycaprolactone (PCL) is investigated. Composites were prepared by compounding PLA or PCL with date pits at 10, 20, 30, and 40% wt/wt and extruded.
A. A. Mohamed, S. Hussain, M. S. Alamri, M. A. Ibraheem, Akram A. Abdo Qasem   +4 more
doaj   +1 more source

Irregular Oscillatory-Patterns in the Early-Time Region of Coherent Phonon Generation in Silicon [PDF]

, 2017
Coherent phonon (CP) generation in an undoped Si crystal is theoretically investigated to shed light on unexplored quantum-mechanical effects in the early-time region immediately after the irradiation of ultrashort laser pulse.
Hase Muneaki, Hino Ken-ichi, Maeshima Nobuya, Watanabe Yohei, 前島 展也, 日野 健一, 長谷 宗明   +6 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Impact of Mechanically-Imposed Shear on Clogging, Fouling and Energy Demand for an Immersed Membrane Bioreactor

Membranes, 2018
The impact of the application of mechanically-imposed shear on the propensity for fouling and clogging (or “sludging„—the agglomeration of sludge solids in the membrane channel) of an immersed flat sheet (iFS) membrane bioreactor (MBR ...
Simon Judd, Albert Odai, Pompilia Buzatu, Hazim Qiblawey   +3 more
doaj   +1 more source

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms

Environmental Health Perspectives, 2010
The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular ...
Feige, J.N., Gerber, A., Casals-Casas, C., Yang, Q., Winkler, C., Bedu, E., Bueno, M., Gelman, L., Auwerx, J., Gonzalez, F.J., Desvergne, B.   +10 more
openaire   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Method of specific energy for determination mechanical characteristics of structural steel (rus) [PDF]

Инженерно-строительный журнал, 2011
The studies performed in present article are directed on improvement the practical methods of the existing steel structures examination. In particular, the new method for the determination of the mechanical properties of steel structure elements of the ...
Levanov A.V., Khomich V.M., Kurlapov D.V.   +2 more
doaj  

Relationship between quantum mechanics with and without monopoles

, 2006
We show that the inclusion of the monopole field in the three- and five-dimensional spherically symmetric quantum mechanical systems, supplied by the addition of the special centrifugal term, does not yield any change in the radial wavefunction and in ...
Armen Nersessian, Armen Yeranyan, Bellucci, Bellucci, Bellucci, Bellucci, Feher, Feher, Gibbons, Gibbons, Gritsev, Higgs, Iwai, Iwai, Kalnins, Leemon, Levon Mardoyan, Mardoyan, Mardoyan, Mardoyan, Mardoyan, Mardoyan, Mardoyan, McIntosh, Meng, Mladenov, Mladenov, Nersessian, Nersessian, Tchrakian, Tolkachev, Tolkachev, Zwanziger   +32 more
core   +1 more source