Results 111 to 120 of about 5,284,833 (331)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Correction mechanism for Raman spectroscopy in emulsions

Analytical and Bioanalytical Chemistry
Abstract When the concentration of a fluid mixture is measured with Raman spectroscopy in emulsions instead of pure liquids, the signal strength is influenced by the light scattering of the droplets which gives wrong results. This work investigates this influence in the example of a water-toluene-acetone emulsion.
Erik Spoor, Matthias Rädle, Jens-Uwe Repke   +2 more
openaire   +2 more sources

Beta relaxation in the shear mechanics of equilibrium viscous liquids: Phenomenology and network modeling of the alpha-beta merging region

, 2010
The phenomenology of the beta relaxation process in the shear-mechanical response of glass-forming liquids is summarized and compared to that of the dielectric beta process.
Barlow, Behrens, Bo Jakobsen, Böhmer, Christensen, Christensen, Christensen, Claudio Maggi, Cole, Debye, Deegan, DiMarzio, Donth, Dyre, Dyre, Díaz-Calleja, Ferry, Gemant, Harrison, Hutcheson, Igarashi, Igarashi, Jakobsen, Jakobsen, Jeppe C. Dyre, Jonscher, Jonscher, Jonscher, Kristine Niss, Maggi, Mandanici, Mandanici, Mandanici, Mandanici, Menon, Ngai, Niels Boye Olsen, Nielsen, Niss, Olsen, Olsen, Olsen, Richert, Sağlanmak, Schröter, Schröter, Sidebottom, Tage Christensen   +47 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Mechanical spectroscopy study of the Cu36Zr59Al5 and Cu54Zr40Al6 amorphous alloys

Materials Research, 2012
A mechanical spectroscopy study of Cu-Zr-Al bulk metallic glasses, was performed with two types of equipment: a Kê-type inverted torsion pendulum and an acoustic elastometer, working in the frequency ranges of Hz and kHz, respectively, with a heating ...
Paulo Wilmar Barbosa Marques, Javier Muñoz Chaves, Paulo Sérgio da Silva Jr., Odila Florêncio, Maira Martins Garcia, Luis César Rodríguez Aliaga, Walter José Botta   +6 more
doaj  

In silico broadband mechanical spectroscopy of amorphous tantala

Physical Review Research, 2019
Adopting an agnostic approach, the quality factor Q of tantala glass is drawn via in silico mechanical spectroscopy in wide ranges of temperature (10–300 K) and frequency (500MHz≤f≤1THz).
F. Puosi, F. Fidecaro, S. Capaccioli, D. Pisignano, D. Leporini   +4 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source