Results 71 to 80 of about 448,246 (218)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fabrication of Surface Embedded Silver Cellulose-based Flexible Transparent Electrodes by Self-Assembly

BioResources
Developing eco-friendly, degradable, and flexible electronic devices using renewable cellulose, such as waste agricultural straw, is increasingly vital. This approach tackles the growing issue of nondegradable electronic waste.
Wentao Zhang, Tianhao Wang, Ying Zhu, Yanan Gao, Lin Liu, Mengling Li, Liping Zhang   +6 more
doaj  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Microstructure and mechanical property regulation of hot-rolled Al-contained medium-Mn steel by double intercritical annealing

Cailiao gongcheng
Usually，the initial microstructure of hot-rolled and quenched medium-manganese experimental steel is composed of lath martensite matrix and a small amount of tiny granular austenite， also existing apparent Mn-segregation bands. Using double intercritical
MAO Peining, HUANG Xingmin, LYU Chao, LIU Junjie, ZHANG Juan   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

In Vitro Micro-CT Assessment of a Novel Implant–Abutment Connection Under Static and Cyclic Loading

Applied Sciences
The implant–abutment connection (IAC) is a critical determinant of the mechanical and biological performance of dental implants. Connection design and insertion torque may influence fatigue resistance, micromovement, and microgap formation, thereby ...
Marco Tallarico, Dario Melodia, Lukasz Zadrozny, Carlotta Cacciò, Silvio Mario Meloni, Aurea Immacolata Lumbau, Santo Catapano, Riccardo Baldari, Rafał Molak, Jakub Jaroszewicz, Gabriele Cervino   +10 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Assessment of the Quality of Structural Steels by their Ability to Resist Brittle Fracture under the Stress Concentration

Механика машин, механизмов и материалов, 2015
New parameter for assessment of structural quality - the measure of structural quality μσPms by the residual mechanical stability Pms is offered. It exhibits their residual possibility to resist embrittlement under the stress concentration.
Artur V. Shiyan, Yuriy Ya. Meshkov
doaj