Activation of Long Descending Propriospinal Neurons in Cat Spinal Cord [PDF]
, 1980 Isolated mammalian spinal cord has been shown capable of generating locomotor activity. Propriospinal systems assumed to coordinate fore- and hindlimb activity are poorly understood.
Adams, Robert J. +2 more
core +2 more sources
Adding memory to pressure-sensitive phosphors [PDF]
, 2019 Mechanoluminescence (ML) is the phenomenon describing the emission of light during mechanical action on a solid, leading to applications such as pressure sensing, damage detection and visualization of stress distributions.
Feng, Ang +3 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Naturally Engineered Maturation of Cardiomyocytes
Frontiers in Cell and Developmental Biology, 2017 Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option.
Gaetano J. Scuderi, Jonathan Butcher
doaj +1 more source
Osteocytes and mechanical loading: The Wnt connection [PDF]
, 2019 Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y +21 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Electrical neurostimulation for chronic pain: on selective relay of sensory neural activities in myelinated nerve fibers [PDF]
, 2015 Chronic pain affects about 100 million adults in the US. Despite their great need, neuropharmacology and neurostimulation therapies for chronic pain have been associated with suboptimal efficacy and limited long-term success, as their mechanisms of ...
Sacré, Pierre +3 more
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Cellular responses to external mechanical stimuli when seeded to 3D collagen [PDF]
, 2005 INTRODUCTION: Collagen is a naturally occurring visco-elastic protein and widely used biomaterial in Tissue engineering. Mechanical stimulation of cell seeded collagen constructs and its effects on cell orientation, intracellular signalling and molecular
Brown, R, Karamichos, D, Mudera, V
core
Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]
, 2010 Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja +5 more
core +2 more sources