Results 81 to 90 of about 3,260,986 (243)

Investigating the Effects of Mechanical Stimulation on Retinal Ganglion Cell Spontaneous Spiking Activity

Frontiers in Neuroscience, 2019
Mechanical forces are increasingly recognized as major regulators of several physiological processes at both the molecular and cellular level; therefore, a deep understanding of the sensing of these forces and their conversion into electrical signals are
Marica Marrese, Davide Lonardoni, Fabio Boi, Hedde van Hoorn, Alessandro Maccione, Stefano Zordan, Davide Iannuzzi, Luca Berdondini   +7 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of the in vitro culture of ovarian cortical tissue strips

Frontiers in Bioengineering and Biotechnology
Introduction: We report the development and preliminary evaluation of a novel dynamic bioreactor to culture ovarian cortical tissue strips that leverages tissue response to enhanced oxygen transport and adequate mechanical stimulation. In vitro multistep
Gionata Fragomeni, Luigi De Napoli, Vincenza De Gregorio, Vincenzo Genovese, Vincenza Barbato, Giuseppe Serratore, Giuseppe Morrone, Angela Travaglione, Andrea Candela, Roberto Gualtieri, Riccardo Talevi, Gerardo Catapano   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Effect of sensory deprivation and Locus Coeruleus (LC) electrical stimulation on the response properties of layer IV barrel cortex neurons in male rats [PDF]

Introduction: Barrel cortex of rodents is responsible for sensory information processing from muzzle whiskers. Locus coeruleus (LC) as the main source of norepinephrine (NE) in the cortex, is effective on the sensory information processing. Methods:
شمسی زاده, علی, سیاه پشت خاچکی, علی, شیبانی, وحید, شیخکانلوی میلان, حمید, آفرینش, محمدرضا   +4 more
core  

Frequency response of human skin in vivo to mechanical stimulation [PDF]

, 2001
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.Includes bibliographical references (p. 49-51).The frequency-dependent response of human skin was measured, in vivo, to mechanical stimulation at a scale useful ...
Diller, Timothy Thomas, 1974-
core  

Soft bioreactor systems: a necessary step toward engineered MSK soft tissue?

Frontiers in Robotics and AI
A key objective of tissue engineering (TE) is to produce in vitro funcional grafts that can replace damaged tissues or organs in patients. TE uses bioreactors, which are controlled environments, allowing the application of physical and biochemical cues ...
Nicole Dvorak, Zekun Liu, Pierre-Alexis Mouthuy   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells

, 2013
A microfluidic microdevice was developed to exert mechanical stimulation on an individual suspension cell for mechanosensation research. In this microfluidic chip, an individual cell was isolated from a population of cells, and trapped in a microchannel ...
Li, Cheuk-Wing, Yao, Xinsheng, MengsuYang, Xu, Tao, Yue, Wanqing, Yang, Mengsu   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source