Results 81 to 90 of about 506,255 (288)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanical stimulation of distraction regenerate. Mini-review of current concepts

Гений oртопедии, 2023
Introduction One of the key limitations of distraction osteogenesis (DO) is the absence or delayed formation of a callus in the distraction gap, which can ultimately prolong the duration of treatment.
Alexander Cherkashin
doaj   +1 more source

Mediators of mechanotransduction between bone cells [PDF]

, 2009
Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and
Komarova, S. V., Lopez, M., Miura, R. M., Qazi, S., Wall, D. J. N.   +4 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Pain perception and migraine [PDF]

, 2018
Background: It is well-known that both inter-and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head.
Coppola, Gianluca, Parisi, Vincenzo, Pierelli, Francesco, Russo, Antonio, Silvestro, Marcello, Tedeschi, Gioacchino, Tessitore, Alessandro   +6 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation

Journal of Biomechanical Science and Engineering, 2018
In this study, a hybrid electromagnetic and mechanical stimulation system that can apply an alternative current magnetic field (ACMF) and tensile strain fields on PC12 cells was developed to enhance nerve axonal extension. For the ACMF stimulation system,
Eiji NAKAMACHI, Kazuya MATSUMOTO, Ryota SAKIYAMA, Koji YAMAMOTO, Yusuke MORITA   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Effect of stimulation frequency on osteogenic capability of electrical muscle stimulation

Journal of Biomechanical Science and Engineering, 2014
Exercise is effective as a preventive modality of osteoporosis because bone formation is accelerated by mechanical loading. However, elderly patients with osteoporosis are often difficult to exercise, which brings some risks of fractures during exercise ...
Shigeo M. TANAKA
doaj   +1 more source

Fine-grained nociceptive maps in primary somatosensory cortex [PDF]

, 2012
Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
,, Haggard, P, Iannetti, GD, Longo, MR, Mancini, F, Sereno, MI   +5 more
core   +2 more sources