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The induction of autophagy by mechanical stress [PDF]
Autophagy, 2011 The ability to respond and adapt to changes in the physical environment is a universal and essential cellular property. Here we demonstrated that cells respond to mechanical compressive stress by rapidly inducing autophagosome formation. We measured this response in both Dictyostelium and mammalian cells, indicating that this is an evolutionarily ...
Jason S KING +2 more
exaly +3 more sources
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Knee osteoarthritis (KOA) is a common chronic disease in orthopedics, which brings great pain to patients' life and spirit. Therefore, it is necessary to elucidate the pathogenesis of KOA.
Wei Jiang +8 more
semanticscholar +1 more source
A Method for Comparing the Fatigue Performance of Forged AZ80 Magnesium
Metals, 2021 A closed die forging process was developed to successfully forge an automotive suspension component from AZ80 Mg at a variety of different forging temperatures (300 °C, 450 °C).
Andrew Gryguć +9 more
doaj +1 more source
The Course of Mechanical Stress: Types, Perception, and Plant Response
Biology, 2023 Simple Summary Mechanical stress is a substantial natural environmental constraint for plants that is induced by dry compacted soils, intense rain and windstorms, changes in gravity, and obstacles.
M. Kouhen +3 more
semanticscholar +1 more source
CdSe and CdTe Mechanical Properties Revealed by COMSOL Multiphasics
Al-Mustansiriyah Journal of Science, 2023 Two Metal chalcogenide compounds CdTe and CdSe have been studied in depth because they are used in many optoelectronic and electronic devices. High pressure causes structural phase transitions in semiconductor materials, which have been the subject of ...
Ali K. Mohammed Ali
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense the changes in mechanical stress and convert the mechanical signals into chemical signals.
Sheng Shi +5 more
semanticscholar +1 more source
Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts
Frontiers in Bioengineering and Biotechnology, 2022 Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and osteogenic activities.
Pan Liu +6 more
semanticscholar +1 more source
Mechanical stress determines the configuration of TGFβ activation in articular cartilage
Nature Communications, 2021 Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear.
G. Zhen +14 more
semanticscholar +1 more source
Mechanical stress driven by rigidity sensing governs epithelial stability
bioRxiv, 2022 On soft substrates, epithelial tissues are under high tension and form holes that spontaneously heal. Thus, mechanical stress directly impacts the integrity of epithelia. Epithelia act as barriers against environmental stresses.
Surabhi Sonam +12 more
semanticscholar +1 more source
Mechanisms of stress in the brain [PDF]
Nature Neuroscience, 2015 The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a sign of successful adaptation ...
Bruce S McEwen +6 more
openaire +3 more sources