Results 11 to 20 of about 7,604,628 (414)

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

Molecular Medicine, 2021
Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction mediated by mechanical stress is still unclear.
Yi Sun, P. Leng, P. Guo, Huanshen Gao, Yikai Liu, Chenkai Li, Zhenghui Li, Haining Zhang   +7 more
semanticscholar   +1 more source

Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway

Frontiers in Pharmacology, 2023
Intervertebral disc degeneration (IDD) is the cardinal pathological mechanism that underlies low back pain. Mechanical stress of the intervertebral disc may result in a change in nucleus pulposus cells state, matrix degradation, and degeneration of the ...
Xin Zhang, Shibin Shu, Zhenhua Feng, Yong Qiu, Hongda Bao, Zezhang Zhu   +5 more
doaj   +1 more source

Mechanical influence of tissue scaffolding design with different geometries using finite element study [PDF]

, 2023
The mechanical properties of tissue scaffolds are essential in providing stability for tissue repair and growth. Thus, the ability of scaffolds to withstand specific loads is crucial for scaffold design.
Roy, Sandipan, Faraji, Foad; id_orcid, Xinyi An, Zohourkari, Iman, Faraji, Foad, Mohammad Hossein Yazdi, Iman Zohourkari, Yazdi, Mohammad Hossein, Merdji, Ali, Moey, Lip Kean, Gnanasagaran, Constance Linda, An, Xinyi, Perk Lin Chong, Foad Faraji, Sandipan Roy, Constance Linda Gnanasagaran, Lip Kean Moey, Chong, Perk Lin, Ali Merdji, Zohourkari , Iman   +19 more
core   +1 more source

Maintaining proteostasis under mechanical stress

EMBO Reports, 2021
Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity.
J. Höhfeld, T. Benzing, W. Bloch, D. Fürst, S. Gehlert, M. Hesse, B. Hoffmann, T. Hoppe, Pitter F. Huesgen, M. Köhn, W. Kolanus, R. Merkel, C. Niessen, Wojciech Pokrzywa, Markus M. Rinschen, D. Wachten, B. Warscheid   +16 more
semanticscholar   +1 more source

Split sleeve cold expansion of AZ31B sheet: Microstructure, texture and residual stress

Materials & Design, 2020
Despite magnesium limited formability at room temperature, split sleeve hole cold expansion of AZ31B sheet was successfully implemented. Microstructural analysis showed greater hardness in the immediate vicinity of the notch, which was due to high ...
Sasan Faghih, Sugrib Kumar Shaha, Seyed Behzad Behravesh, Hamid Jahed   +3 more
doaj   +1 more source

Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions

Frontiers in Bioengineering and Biotechnology, 2023
In biotechnological processes, filamentous microorganisms are known for their broad product spectrum and complex cellular morphology. Product formation and cellular morphology are often closely linked, requiring a well-defined level of mechanical stress ...
Marcel Schrader, Marcel Schrader, Kathrin Schrinner, Kathrin Schrinner, Laura Polomsky, Laura Polomsky, Dimitri Ivanov, Dimitri Ivanov, Ingo Kampen, Ingo Kampen, Carsten Schilde, Carsten Schilde, Rainer Krull, Rainer Krull, Arno Kwade, Arno Kwade   +15 more
doaj   +1 more source

KATANIN and CLASP function at different spatial scales to mediate microtubule response to mechanical stress in Arabidopsis cotyledons.

Current Biology, 2021
Mechanical stress influences cell- and tissue-scale processes across all kingdoms. It remains challenging to delineate how mechanical stress, originating at these different length scales, impacts cell and tissue form. We combine growth tracking of cells,
R. Eng, René Schneider, Timon W. Matz, Ross Carter, D. Ehrhardt, H. Jönsson, Z. Nikoloski, Arun Sampathkumar   +7 more
semanticscholar   +1 more source

Understanding the mechanisms of lung mechanical stress [PDF]

Brazilian Journal of Medical and Biological Research, 2006
Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These
Garcia, C. S. N. B., Prota, L. F. M., Morales, M. M., Romero, Pablo V., Zin, W. A., Rocco, P. R. M.   +5 more
openaire   +6 more sources

Double-Facet Effect of Artificial Mechanical Stress on Red Blood Cell Deformability: Implications for Blood Salvage

Applied Sciences, 2022
The use of intra-operative blood salvage, dialysis, and artificial organs are associated with the application of non-physiological mechanical stress on red blood cells (RBCs).
Tamir Tsohar, Shaul Beyth, Alexander Gural, Dan Arbell, Saul Yedgar, Gregory Barshtein   +5 more
doaj   +1 more source

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Cell, 2020
Summary Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We
Michele M. Nava, Y. Miroshnikova, Leah C. Biggs, Daniel B. Whitefield, F. Metge, Jorge Bouças, H. Vihinen, E. Jokitalo, Xinping Li, Juan Manuel García Arcos, B. Hoffmann, R. Merkel, C. Niessen, K. Dahl, S. Wickström   +14 more
semanticscholar   +1 more source