Results 121 to 130 of about 1,739,618 (296)
Nonlinear laminate analysis for metal matrix fiber composites [PDF]
A nonlinear laminate analysis is described for predicting the mechanical behavior (stress-strain relationships) of angleplied laminates in which the matrix is strained nonlinearly by both the residual stress and the mechanical load and in which ...
Chamis, C. C., Sinclair, J. H.
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Force-Loaded Cementocytes Regulate Osteoclastogenesis Via S1p/S1pr1/ Rac1 Axis
International Dental JournalAim or purpose: This study elucidates the pivotal role of the sphingosine-1-phosphate (S1P)/S1PR1/Rac1 axis in cementocyte-regulated osteoclastogenesis during orthodontically induced inflammatory root resorption (OIIRR).
Han Wang
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Development of Primary Cell Cultures from Haplochromine Cichlid Bone-Derived Tissues
FishesBone is a dynamic tissue with ecological and evolutionary importance, as it can grow and remodel itself in response to mechanical stimuli. In mammals, osteocytes are widely recognised as the central regulators of bone formation and mechanotransduction ...
Deepti Negi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Research progress on the role of biomechanical clues in the progression of lung cancer
Frontiers in Cell and Developmental BiologyCells in mammals perceive and react to the mechanical properties of their surrounding environment. Disease progression is frequently linked to dynamic changes in cellular and tissue mechanics.
Fengying Gong +9 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Mechanical evaluation of EGUH burs in dentin during guided endodontics: Finite element analysis
Saudi Endodontic JournalIntroduction: This study investigated the mechanical and thermal behavior of EGUH burs used in guided endodontics through simulations performed using Finite Element Analysis.
Luis Geovanny Suárez Guerrero +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source