Results 101 to 110 of about 536,244 (268)
Force-Loaded Cementocytes Regulate Osteoclastogenesis Via S1p/S1pr1/ Rac1 Axis
International Dental JournalAim or purpose: This study elucidates the pivotal role of the sphingosine-1-phosphate (S1P)/S1PR1/Rac1 axis in cementocyte-regulated osteoclastogenesis during orthodontically induced inflammatory root resorption (OIIRR).
Han Wang
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Development of Primary Cell Cultures from Haplochromine Cichlid Bone-Derived Tissues
FishesBone is a dynamic tissue with ecological and evolutionary importance, as it can grow and remodel itself in response to mechanical stimuli. In mammals, osteocytes are widely recognised as the central regulators of bone formation and mechanotransduction ...
Deepti Negi +3 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Research progress on the role of biomechanical clues in the progression of lung cancer
Frontiers in Cell and Developmental BiologyCells in mammals perceive and react to the mechanical properties of their surrounding environment. Disease progression is frequently linked to dynamic changes in cellular and tissue mechanics.
Fengying Gong +9 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Mechanical evaluation of EGUH burs in dentin during guided endodontics: Finite element analysis
Saudi Endodontic JournalIntroduction: This study investigated the mechanical and thermal behavior of EGUH burs used in guided endodontics through simulations performed using Finite Element Analysis.
Luis Geovanny Suárez Guerrero +3 more
doaj +1 more source
Involvement of mechanical stress in androgenetic alopecia
International Journal of Trichology, 2015 Androgenetic alopecia (AGA) is a frequent disorder characterized by progressive hair miniaturization in a very similar pattern among all affected men. The pathogenesis is related to androgen-inducible overexpression of transforming growth factor β-1 from balding dermal papilla cells, which is involved in epithelial inhibition and perifollicular ...
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Advanced ScienceMaxillary underdevelopment is a critical component of skeletal Class III malocclusion, closely linked to altered biomechanical signaling. Mechanical stimulation through early facemask protraction can effectively promote maxillary growth, yet the ...
Yiwen Zhou +15 more
doaj +1 more source