Results 231 to 240 of about 1,739,618 (296)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Mechanical stress-induced autophagy is cytoskeleton dependent. [PDF]

Cell Prolif
Liu L, Zheng W, Wei Y, Li Q, Chen N, Xia Q, Wang L, Hu J, Zhou X, Sun Y, Li B.   +10 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

In vitro analysis of the sealing ability of different root canal sealers under thermo-mechanical stress. [PDF]

Bioinformation
Azad A, Mashalkar V, Agrawal R, Fu Y, Chaudhari D, Haldia A, Mehta M.   +6 more
europepmc   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Hypoxia- and mechanical stress-induced upregulation of mitochondrial HSP60 is associated with phenotypic switching of pulmonary arterial smooth muscle cells. [PDF]

Cell Stress Chaperones
Liu G, Nie H, Zhang X, Huang ZS, Yoshiura KI, Liu KX, Liu Y, Li TS.   +7 more
europepmc   +1 more source

Different effects of abnormal mechanical stress on temporomandibular joint cartilage, subchondral bone, and discs. [PDF]

Front Physiol
Xiao M, Ni S.
europepmc   +1 more source

Traumatic carotid artery dissection and occlusion caused by repetitive mechanical stress to the neck while carrying a mikoshi (portable shrine): illustrative case. [PDF]

J Neurosurg Case Lessons
Sato A, Ikeda H, Akaike N, Yoshida S, Osuki T, Kinosada M, Uezato M, Kurosaki Y, Chin M.   +8 more
europepmc   +1 more source

Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model. [PDF]

J Clin Invest
Gursky Z, Khan ZN, Koundal S, Bhardwaj A, Caceres Melgarejo J, Xu K, Chen X, Lin HM, Gu X, Lee H, Kipnis J, Dori Y, Tannenbaum A, Santambrogio L, Benveniste H.   +14 more
europepmc   +1 more source

NAD⁺/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress. [PDF]

Prog Orthod
Ren H, Wang J, Liu J, Zhang Z, Wang L, Wei F.   +5 more
europepmc   +1 more source