Results 221 to 230 of about 7,604,628 (414)

Thermally Induced Rock Stress Increment And Rock Reinforcement Response

, 2016
The thermal heating caused by the deposition of spent nuclear fuel containers increases the in situ rock stress during disposal time. The thermal stress increase was modelled using thermo-mechanical modelling.
Hakala, Matti, Suikkanen, Johannes, Uotinen, Lauri, Nuijten, Guido, Siren, Topias, Ström, Jesse   +5 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Residual Stresses in Shot-Peened Mechanical Structural Carbon Steel Using High-Energy X-Rays [PDF]

Chang-Hwan Bae, Seung-In Lim, Chang-Suk Han   +2 more
openalex   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of laser heating on mechanical properties, residual stresses and retardation of fatigue crack growth in AA2024 [PDF]

, 2020
Nikolai Kashaev, Anne Groth, Volker Ventzke, Μ. Horstmann, Stefan Riekehr, Peter Staron, N. Huber   +6 more
openalex   +1 more source

Growth Inhibition by Mechanical Stress [PDF]

Science, 1971
R, Turgeon, J A, Webb
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mechanical Stress Induces VEGF Expression and RPE Disruption in Mouse Eyes. [PDF]

Biology (Basel)
Minamoto A, Ko JA, Haruyama K, Ashimori A, Kimura K, Kiuchi Y, Sakaguchi H.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress. [PDF]

Cartilage
Takesue S, Hirose N, Yanoshita M, Nishiyama S, Tsuboi E, Kubo N, Kita D, Asakawa Y, Tanimoto K.   +8 more
europepmc   +1 more source