Results 111 to 120 of about 1,697,500 (308)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Effectiveness of spacecraft testing programs [PDF]
The need for testing under simulated mission operational conditions is discussed and the results of such tests are reviewed from the point of view of the user.
Krausz, A.
core +1 more source
AiResearch QCGAT engine performance and emissions tests [PDF]
, 1980 Results of aerodynamic performance and emission tests, conducted on a specially designed QCGAT engine in the 17,793-N (4,000 lb) thrust class, are presented. Performance of the AiResearch QCGAT engine was excellent throughout all testing.
Norgren, W. M.
core +1 more source
Unfolding and unzipping of single-stranded DNA by stretching
, 2004 We present a theoretical study of single-stranded DNA under stretching. Within the proposed framework, the effects of basepairing on the mechanical response of the molecule can be studied in combination with an arbitrary underlying model of chain ...
Alexei V. Tkachenko +4 more
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Torsion pendulum measurements on viscoelastic materials during vacuum exposure [PDF]
A torsional pendulum apparatus designed for testing in situ in vacuum, the dynamic mechanical properties of materials is described. The application of this apparatus to an experimental program to measure the effects of vacuum on the mechanical properties
Evans, M. L., Ward, T. C.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
High-power baseline and motoring test results for the GPU-3 Stirling engine [PDF]
Test results are given for the full power range of the engine with both helium and hydrogen working fluids. Comparisons are made to previous testing using an alternator and resistance load bank to absorb the engine output.
Thieme, L. G.
core +1 more source