Results 131 to 140 of about 1,715,737 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Large Eddy Simulation of a Turbulent Flow over Circular and Mixed Staggered Tubes’ Cluster

Journal of Applied Fluid Mechanics, 2020
A large eddy simulation study was conducted to investigate the turbulent dynamic structure of a fluid flow in two staggered tube configurations, one is composed of all circular cylinders and the second is composed of circular and square cylinders.
M. Bedrouni, A. Khelil, M. Braikia, H. Naji   +3 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Guidelines for ex vivo mechanical testing of tendon. [PDF]

J Orthop Res, 2023
Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC, Thomopoulos S.   +5 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Development and Experimental Study of an Experimental Setup for an Online Vibrating Tube Liquid Densitometer

Applied Sciences
Density is a crucial parameter for quantitatively describing the physical properties of liquids. It serves as an important indicator for scientific research, production process control, pipeline transportation, and other aspects.
Defu Xu, Yaoning Sun, Welin Chen, Jun Mu, Wang Peng   +4 more
doaj   +1 more source

Development of a ferromagnetic rotary vacuum sealed spacecraft spin fixture [PDF]

A number of successful spacecraft tests were conducted on an environmental spin fixture which utilizes a ferrofluidic rotary vacuum seal. The 27 cm (10.5 inch) diameter fixture drive shaft supports and spins communications satellites during flight ...
Levine, M. B.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Non-destructive evaluation of defects in thermal barrier coating system using combined electromagnetic and thermographic signals

Nature Communications
Thermal barrier coating system plays key role in high temperature gas turbine blades. During the manufacture and in-service processes, defects are inevitable due to the inconsistent deformation and fatigue loading. The typical defects, e.g.
Jialun Li, Zongfei Tong, Qingning Yang, Jiahao Wang, Chenyu Jia, Wei Guo, Yuange Zhang, Peng Jiang, Wei Qiu, Tetsuya Uchimoto, Shejuan Xie, Zhenmao Chen, Tiejun Wang   +12 more
doaj   +1 more source