Results 31 to 40 of about 1,715,737 (308)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Multi-Objective Optimization of the Microchannel Heat Sink Used for Combustor of the Gas Turbine

Energies
This research presents a surrogate model and computational fluid dynamic analysis-based multi-objective optimization approach for microchannel heat sinks.
Xiaoming Zhang, Tao Yang, Zhenyuan Chang, Liang Xu, Lei Xi, Jianmin Gao, Penggang Zheng, Ran Xu   +7 more
doaj   +1 more source

The thermo-mechanical performance of glass-fibre reinforced Polyamide 66 during glycol-water hydrolysis conditioning [PDF]

, 2010
Injection moulded glass-fibre reinforced polyamide 66 composites based on two glass fibre products with different sizing formulations and unreinforced polymer samples have been characterised by dynamic mechanical analysis and unnotched Charpy impact ...
Ali, J.Z., Anderson, J., Thomason, J.L.
core   +1 more source

A Dynamic Scheduling Method Combining Iterative Optimization and Deep Reinforcement Learning to Solve Sudden Disturbance Events in a Flexible Manufacturing Process

Mathematics
Unpredictable sudden disturbances such as machine failure, processing time lag, and order changes increase the deviation between actual production and the planned schedule, seriously affecting production efficiency. This phenomenon is particularly severe
Jun Yan, Tianzuo Zhao, Tao Zhang, Hongyan Chu, Congbin Yang, Yueze Zhang   +5 more
doaj   +1 more source

Dynamic Characteristics of Rotor System with a Slant Crack Based on Fractional Damping

Chinese Journal of Mechanical Engineering, 2021
The traditional modeling method of rotor system with a slant crack considers only integer-order calculus. However, the model of rotor system based on integer-order calculus can merely describe local characteristics, not historical dependent process.
Zhinong Li, Yunlong Li, Dong Wang, Zhike Peng, Haifeng Wang   +4 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Graphene/Insulator Stack Based Ultrasensitive Terahertz Sensor With Surface Plasmon Resonance

IEEE Photonics Journal, 2017
We proposed a terahertz (THz) surface plasmon resonance (SPR) sensor with Kretschmann coupling configuration with buffer layer covered substrate containing doped monolayer graphene (MLG) directly deposited onto the coupling prism.
Yi Huang, Shuncong Zhong, Yaochun Shen, Ligang Yao, Yingjie Yu, Daxiang Cui   +5 more
doaj   +1 more source

Determination of wood strength properties through standard test procedures [PDF]

, 2012
In this study a review of existing recognised standards for wood mechanical testing was conducted. This review considers tensile, compressive, bending and shear test methodologies from a range of sources.
Hackney, Philip, Naylor, Andrew, Perera, Noel   +2 more
core  

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source