Results 51 to 60 of about 585,172 (311)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Torque modeling of a novel magnetic coupler with multi-disk flux regulation via angular displacement: analytical FEM co-design [PDF]

Mechanical Sciences
This paper proposes a novel axially fixed multi-disk magnetic flux-regulatable magnetic coupler with modular topology, which addresses critical limitations such as the structural scalability of conventional magnetic couplers.
S. Zheng, S. Zheng, C. Yang, C. Yang, Z. Tang, B. Liu   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mechanical testing of solid materials at the micro-scale [PDF]

, 2002
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.Includes bibliographical references (p. 145-149).Successful design and fabrication of structures and systems at the micro-scale requires a sound theoretical ...
Gudlavalleti, Sauri, 1978-
core  

LSE method using the CHSS model [PDF]

, 2009
Testing the reliability at a nominal stress level may lead to extensive test time. Estimations of reliability parameters can be obtained faster thanks to step-stress accelerated life tests (ALT). Usually, a transfer functional defined among a given class
Guerin, Francis, GUERIN, Fabrice, P. Lantieri, LANTIERI, Pascal, F. Guérin, S. Voiculescu, VOICULESCU, Sorin   +6 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Polycaprolactone strengthening gelatin/nano-hydroxyapatite composite biomaterial inks for potential application in extrusion-based 3D printing bone scaffolds

Collagen and Leather
Extrusion-based three-dimensional (3D) printing of gelatin (Gel) is crucial for fabricating bone tissue engineering scaffolds via additive manufacturing.
Chenxin Wang, Mao Yang, Li Chen, Yijing Stehle, Mingyue Lin, Rui Zhang, Huanshuo Zhang, Jiehui Yang, Min Huang, Yubao Li, Qin Zou   +10 more
doaj   +1 more source

A Review on Application of Pin-Fins in Enhancing Heat Transfer

Energies
The pin-fin is one of the main technologies in enhancing heat transfer. The accelerated flow and vortex structures are produced, which can disrupt the development of the flow boundary layer.
Tao Yang, Xiaoming Zhang, Zhenyuan Chang, Ran Xu, Jiaojiao Ma, Liang Xu, Lei Xi   +6 more
doaj   +1 more source