Results 41 to 50 of about 2,688,635 (294)

Successful thrombolytic therapy using ultraslow low-dose infusion during pregnancy for mitral mechanical valve thrombosis: a case series and review of the literature

European Journal of Case Reports in Internal Medicine, 2023
According to the modified World Health Organization (WHO) classification, pregnant women with mechanical valves face a very high risk of complications (Risk Category III). Mechanical valve thrombosis is a serious complication that significantly increases
Leila Bigdelu, Ossama Maadarani, Asal Yadolh, Zouheir Bitar, Nadia Azadi   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A “tilt” toward cinefluoroscopy

Clinical Case Reports, 2018
Key Clinical Message Fluoroscopy permits rapid and straightforward assessment of mechanical valve function and allows a distinction between normal and malfunctional prostheses, acting as a complementary diagnostic step.
Konstantinos Lampropoulos, Athanasios Bakalakos, George Bazoukis, Athanasios Saplaouras, Antigoni Sakellaropoulou, Aikaterini Anagnostou, Gary Tse, Michalis Tsamatsoulis, Christos Charitos   +8 more
doaj   +1 more source

Pregnancy outcomes in women with a mitral valve prosthesis: A systematic review and meta-analysisCentral MessagePerspective

JTCVS Open, 2023
Objectives: To evaluate the ongoing debate concerning the choice of valve prosthesis for women requiring mitral valve replacement (MVR) and who wish to conceive. Bioprostheses are associated with risk of early structural valve deterioration.
Pepijn Grashuis, BSc, Shanti D.M. Khargi, BSc, Kevin Veen, BSc, PhD, Azzeddine el Osrouti, BSc, Shirin Bemelmans-Lalezari, MD, PhD, Jérôme M.J. Cornette, MD, PhD, Jolien W. Roos-Hesselink, MD, PhD, Johanna J.M. Takkenberg, MD, PhD, Mostafa M. Mokhles, MD, PhD   +8 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The effect of valve noise on the quality of life of patients after mechanical mitral valve replacement in a Chinese population

Journal of Cardiothoracic Surgery, 2019
Objective To investigate the effect of valve noise on the quality of life (QOL) in Chinese patients who underwent mechanical mitral valve replacement. Methods We enrolled a total of 103 patients who underwent mechanical mitral valve replacement (MVR, CM ...
Zhi-Nuan Hong, Jiang-Shan Huang, Li-Qin Huang, Hua Cao, Qiang Chen   +4 more
doaj   +1 more source

Clinical Significance of Ventricular Tachyarrhythmias in Patients Undergoing Valve Replacement: A Nationwide Population-Based Study

Frontiers in Cardiovascular Medicine, 2021
Background: The clinical significance and outcomes of ventricular tachyarrhythmias (VTa) in patients undergoing valve replacement have rarely been reported.Objective: This study aimed to investigate the incidence and outcome of VTa after surgical valve ...
Guan-Yi Li, Yun-Yu Chen, Yun-Yu Chen, Kuo-Liong Chien, Yenn-Jiang Lin, Yenn-Jiang Lin, Tzu-Ting Kuo, Tzu-Ting Kuo, Fa-Po Chung, Fa-Po Chung   +9 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Comparison of mechanical versus bioprosthetic valve replacement in mitral stenosis surgery

BMC Cardiovascular Disorders
Background Mitral stenosis is a common valvular heart disease, and the choice of valve material during surgical treatment significantly impacts patient prognosis.
Jinfeng Ma, Qingming Xue
doaj   +1 more source