Results 221 to 230 of about 2,580,895 (365)

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

open access: yesAdvanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang   +10 more
wiley   +1 more source

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

open access: yesAdvanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li   +13 more
wiley   +1 more source

A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome

open access: yesCritical Care Medicine, 2017
B. Fuller   +12 more
semanticscholar   +1 more source

Immunocompatible Elastomer With Enhanced Fibrous Capsule‐Resistance and Elasticity by Water‐Induced Surface Phase Reconfiguration.

open access: yesAdvanced Science, EarlyView.
This study introduces a strategy for engineering heterogeneous surface and bulk structures within a single material, termed phase‐separation and underwater reconfiguration‐enhanced (PURE) elastomers. These elastomers combine high bulk elasticity with enhanced immunocompatibility at the surface.
Xianchi Zhou   +10 more
wiley   +1 more source

Sharing Mechanical Ventilator: In Vitro Evaluation of Circuit Cross-Flows and Patient Interactions. [PDF]

open access: yesMembranes (Basel), 2021
Colombo SM   +13 more
europepmc   +1 more source

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