Results 91 to 100 of about 1,084,896 (304)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Probability in modal interpretations of quantum mechanics [PDF]
, 2007 Modal interpretations have the ambition to construe quantum mechanics as an objective, man-independent description of physical reality. Their second leading idea is probabilism: quantum mechanics does not completely fix physical reality but yields ...
Dieks, Dennis
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Mechanics of materials and structures /
, 1994 A wide range of topics in the area of mechanics of materials and structures are covered in this volume, ranging from analysis to design. There is no special emphasis on a specific area of research.
Bieniek Symposium on Mechanics of Materials and Structures(1993 :University of Virginia) +4 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Between Laws and Models: Some Philosophical Morals of Lagrangian Mechanics [PDF]
, 2004 I extract some philosophical morals from some aspects of Lagrangian mechanics. (A companion paper will present similar morals from Hamiltonian mechanics and Hamilton-Jacobi theory.) One main moral concerns methodology: Lagrangian mechanics provides a ...
Butterfield, Jeremy
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Kinematics in the Information Age
Mathematics, 2018 Modern kinematics derives directly from developments in the 1700s, and in their current instantiation, have been adopted as standard realizations…or templates that seem unquestionable.
Brendon Smeresky +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Bohmian mechanics without wave function ontology [PDF]
, 2013 In this paper I critically assess different three-dimensionalist interpretations of Bohmian mechanics in order to evaluate the prospects of interpreting Bohmian mechanics without committing to a wave function-based ontology.
Solé, Albert
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