Results 71 to 80 of about 2,174,025 (284)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Compressive Response of Non-slender Octet Carbon Microlattices
Frontiers in Materials, 2019 Lattices are periodic three-dimensional architected solids designed at the micro and nano-scale to achieve unique properties not attainable by their constituent materials.
Akira Kudo +3 more
doaj +1 more source
On the link between mechanics and thermal properties: mechanothermics
New Journal of Physics, 2023 We report on the theoretical derivation of macroscopic thermal properties (specific heat, thermal conductivity) of an electrically insulating rod connected to two reservoirs, from the linear superposition of its mechanical mode Brownian motions.
Eddy Collin +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Frontiers in Materials, 2019 In liquid-phase exfoliation for the production of 2D nanomaterials fluid forces are used to gently overcome adhesive interlayer forces, leading to single- or few-layer 2D nanomaterials.
Lorenzo Botto, Lorenzo Botto
doaj +1 more source
Mechanisms of Teratogenesis [PDF]
American Journal of Anatomy, 1972 Man’s early pictorial and written records make it clear that he was aware of and curious about the structural defects that from birth afflicted some of his fellow men. His attitudes about these congenital variants have ranged widely in different cultures: from romanticizing them in mythology, to using them as portent of coming events, to accepting them
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2009 In the oil and gas industry, an underreamer is a tool used to extend and enlarge the diameter of a previously-drilled bore. The problem proposed to the Study Group is to obtain appropriate mathematical models of underreamer dynamics, in forms that will ...
Barton, David +8 more
core
THE MECHANICS AND MECHANISMS OF TOURISM BROKERING
Ethnologia Europaea, 2018 Although most forms of tourism are, and have always been, highly mediated activities, surprisingly little scholarly attention has been given to the crucial role of human brokers in tourism.
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source