Results 31 to 40 of about 1,969,503 (237)

Underreamer mechanics [PDF]

open access: yes, 2009
In the oil and gas industry, an underreamer is a tool used to extend and enlarge the diameter of a previously-drilled bore. The problem proposed to the Study Group is to obtain appropriate mathematical models of underreamer dynamics, in forms that will ...
Barton, David   +8 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mesoscopic Mechanics

open access: yes, 2003
This article is concerned with the existence, status and description of the so-called emergent phenomena believed to occur in certain principally planar electronic systems. In fact, two distinctly different if inseparable tasks are accomplished. First, a
Artur Sowa   +9 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Singularity in classical and quantum Kepler Problem with Weak Anisotropy

open access: yes, 2001
Anisotropic Kepler problem is investigated by perturbation method in both classical and quantum mechanics. In classical mechanics, due to the singularity of the potential, global diffusion in phase space occurs at an arbitrarily small perturbation ...
Arnold   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Certification Can Count: The Case of Aircraft Mechanics [PDF]

open access: yes, 2002
[Excerpt] In 2000, aircraft mechanics and service technicians certified by the Federal Aviation Administration (FAA) earned on average $20.16 per hour. Aircraft mechanics and technicians without FAA certification earned on average $15.78 per hour, over ...
Bureau of Labor Statistics
core   +1 more source

Moral Mechanisms [PDF]

open access: yesPhilosophy & Technology, 2014
As highly intelligent autonomous robots are gradually introduced into the home and workplace, ensuring public safety becomes extremely important. Given that such machines will learn from interactions with their environment, standard safety engineering methodologies may not be applicable.
openaire   +4 more sources

Home - About - Disclaimer - Privacy