Results 61 to 70 of about 219,378 (217)

Research Progress and Engineering Applications of Viscous Fluid Mechanics

Applied Sciences
This paper systematically reviews the development of viscous fluid mechanics and expounds the current research status of viscous fluid mechanics from the aspects of permeability experiments and research on viscous fluids, particle distribution and ...
Jianjun Peng, Run Feng, Meng Xue, Erhao Zhou, Junhua Wang, Zhidan Zhong, Xiangchen Ku   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Fracture Mechanics in the Service of Mechanical Engineering

Механика машин, механизмов и материалов, 2012
The foundations of a new engineering approach to the calculation and experimental evaluation of the cyclic crack resistance of ductile steels, based on the measurement of local plastic deformation of the dangerous section of the sample in the vicinity of
A.V. Bogdanovich , A.E. Shishkin
doaj  

Exploration and practice in digital rock mechanics engineering

Meitan kexue jishu
Traditional mining engineering has long been trapped in the dilemma of “coexistence of mining operations and inherent risks”. The duality of its high-risk nature and resource contribution has become increasingly prominent under deep mining conditions. As
Hegang QI, Haitao LI, Jianwei ZHENG, Qingxin QI, Feng CAI, Baoyan ZHI, Guanchao MA, Jinguo WANG, Shanshan XUE, Haikuan ZHANG, Liang ZHANG, Chi LIU, YIqin LIU   +12 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Mechanics+Mechanical Engineering: Algorithm of Intensive Innovational Development

Механика машин, механизмов и материалов, 2007
The base directions of realization of the State program of country innovational development for 2006—2010 years in the field of mechanical engineering, which are coordinated and carried out within the framework of the State complex goal-oriented ...
V.I. Semashko, M.S. Vysotsky
doaj  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Emerging Trends in Structural Mechanics Education: A Bibliometric Approach from the Perspective of Colombian Professors

Buildings
Recent developments in higher education have transformed teaching–learning processes across disciplines, including structural mechanics in civil engineering programs.
Jesús D. Villalba-Morales, Sandra Jerez, Ricardo Parra, Juan C. Obando, Andrés Guzmán, José M. Benjumea, Orlando Arroyo, Orlando Cundumi   +7 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source