Results 61 to 70 of about 173,631,140 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

20th Australasian Conference on the Mechanics of Structures and Materials (ACMSM20)

, 2009
Futures in Mechanics of Structures and Materials is a collection of peer-reviewed papers presented at the 20th Australasian Conference on the Mechanics of Structures and Materials (ACMSM20, University of Southern Queensland, Toowoomba, Queensland ...
Aravinthan, Thiru, Karunasena, Warna (Karu), Wang, Hao   +2 more
core   +1 more source

Stress singularities in CLT with holes and notches: A unified FE–LEFM framework validated on extensive experimental evidence

Results in Engineering
Cross-laminated timber (CLT) members with geometric discontinuities such as holes and notches exhibit pronounced stress concentrations, which lead to stress singularities in linear elastic finite element (FE) analyses and complicate structural ...
Markus Detter, Georg Hochreiner, Markus Lukacevic, Josef Füssl   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Nonlinear buckling analysis of porous-core FG-GPLRC toroidal shell segments with generalized meridional curvature reinforced by orthogonal stiffeners

Vietnam Journal of Mechanics
By utilizing the Donnell shell theory with von K\'{a}rm\'{a}n strain-displacement relationship, the nonlinear buckling behavior of porous core functionally graded graphene platelet-reinforced composite (FG-GPLRC) toroidal shell segments with generalized
Vu Hoai Nam, Kieu Lan Huong, Le Ngoc Ly, Cao Van Doan, Pham Thanh Hieu   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Quasistaticity of the process of dynamic strain of soils

Инженерно-строительный журнал, 2019
Mechanical characteristics of soil under static and dynamic strains are determined experimentally. Their accuracy and reliability depends on quasi-static nature of strain process in soil.
Karim Sultanov, Pavel Loginov, Sabida Ismoilova, Zulfiya Salikhova   +3 more
doaj   +1 more source

Mechanisms meet structural explanation [PDF]

Synthese, 2015
This paper investigates the relationship between Structural Explanation and the New Mechanistic account of explanation. The aim of this paper is twofold: firstly, to argue that some phenomena in the domain of fundamental physics, although mechanically brute, are structurally explained; and secondly, by elaborating on the contrast between SE and ME, to ...
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source