Results 141 to 150 of about 7,498,964 (312)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Context-mechanism-outcome configurations of target clinics.
, 2018 Context-mechanism-outcome configurations of target clinics.
Calanit Key (4962046) +5 more
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Quantitative Evaluation of Thumb Degrees of Freedom Relevance in Anthropomorphic Robot Hands
RoboticsThumb degree-of-freedom (DOF) allocation in anthropomorphic robot hands involves a trade-off between functional mobility and mechanical-control complexity.
Sebastian Polzin +6 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
openStudio di diverse configurazioni di leg mechanism, analisi di vari parametri per ogni meccanismo e successivo confronto tra di essi. L'obiettivo è quello di avere poi la possibilità di valutare quale tra i vari tipi di meccanismo sia il migliore in
LOFOCO, GREGORIO
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A low-frequency pendulum mechanism
, 2014 A pendulum mechanism is presented whose natural frequency of oscillation is distinctly lower than that of a conventional pendulum of comparable size. Furthermore, its natural frequency is approximately proportional to its amplitude of oscillation.
Starossek, Uwe
core +1 more source