Results 191 to 200 of about 2,474,961 (353)

Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies [PDF]

, 2015
Jia, Xiaofeng, Romero-Ortega, Mario I., Teng, Yang D.   +2 more
core   +1 more source

Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity. [PDF]

PLoS Comput Biol
Kim G, Kim P.
europepmc   +1 more source

Vascular biology: New mechanisms and pathways [PDF]

Vascular Pharmacology, 2016
Dulak, J, Alexander, MY, Randi, AM
openaire   +5 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Correction: A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC. [PDF]

Cell Mol Biol Lett
Wang Z, Wu Y, Ding Z, Xiao X, Huang Y, Liu Z, Zhang Q.   +6 more
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Branched-chain amino acids alleviate sepsis-induced myocardial dysfunction via inhibition of protein tyrosine phosphatase-6

Signal Transduction and Targeted Therapy
Shu-Rui Pang, Yu-Tong Zhu, Hou-Zao Chen, Jian-Fei Pei, De-Pei Liu   +4 more
doaj   +1 more source

Condensate dynamics at the synapse: Phase separation tunes presynaptic function. [PDF]

PLoS Biol
Lützkendorf J, Sigrist SJ.
europepmc   +1 more source

Modeling of the Bacterial Mechanism of Methicillin-Resistance by a Systems Biology Approach

, 2009
Ida Autiero, Susan Costantini, Giovanni Colonna   +2 more
openalex   +2 more sources

Target identification and mechanism of action in chemical biology and drug discovery [PDF]

, 2013
Monica Schenone, Vlado Dančík, Bridget K. Wagner, Paul A. Clemons   +3 more
openalex   +1 more source