Results 201 to 210 of about 10,501,738 (419)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Protocol for identifying protein synthesis activity in specific cell types of the testicular lumen

STAR Protocols
Summary: Protein synthesis could control spermatogenic cell fate transitions. Here, we present a protocol for visualization and quantification of newly synthesized proteins by click-chemistry-based immunofluorescence within specific spermatogenic cell ...
Dingfeng Zou, Kai Li, Yan Lu, Wei Yan, Wei Song   +4 more
doaj  

A Novel Mechanism of PPARγ Regulation of TGFβ1: Implication in Cancer Biology [PDF]

, 2008
Chang Ho Lee, Hyung Don Kim, Sang Mi Shin, Sang Geon Kim   +3 more
openalex   +1 more source

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Nature Reviews. Cancer, 2016
S. Topalian, J. Taube, R. Anders, D. Pardoll   +3 more
semanticscholar   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Editorial: Hallmark of cancer: Resisting cell death

Frontiers in Oncology, 2022
Yichao Zhu, Yichao Zhu, Risheng Yang, Risheng Yang, Jacqueline H. Law, Muhammad Khan, Kenneth W. Yip, Qiang Sun, Qiang Sun   +8 more
doaj   +1 more source

Floral biology and mechanisms of spontaneous self-pollination in five neotropical species of Gentianaceae [PDF]

, 2009
Leandro Freitas, Marlies Sazima
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Decoding ALS: from genes to mechanism

Nature, 2016
J. Taylor, Robert H. Brown, D. Cleveland, D. Cleveland   +3 more
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source