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Mechanical regulation of oligodendrocyte biology
Neuroscience Letters, 2020Oligodendrocytes (OL) are a subset of glial cells in the central nervous system (CNS) comprising the brain and spinal cord. The CNS environment is defined by complex biochemical and biophysical cues during development and response to injury or disease.
Ekta P. Makhija +3 more
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Statistical mechanics meets single-cell biology
Nature Reviews Genetics, 2021Single-cell omics is transforming our understanding of cell biology and disease, yet the systems-level analysis and interpretation of single-cell data faces many challenges. In this Perspective, we describe the impact that fundamental concepts from statistical mechanics, notably entropy, stochastic processes and critical phenomena, are having on single-
Andrew E. Teschendorff +1 more
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Molecular quantum mechanics in biology
Quarterly Reviews of Biophysics, 1969Among the different fields of natural sciences, physics is concerned with the most basic properties of matter. It is possible to define the necessary physical concepts in a rather unique way and carry out experiments under well-controlled conditions. The interpretation of experiments is therefore comparatively easy.
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MOLECULAR MECHANISMS IN DEVELOPMENTAL BIOLOGY
Cell Biology International, 1996AbstractSome general molecular mechanisms underlying development are described. Namely: those involved in the differentiation of the R7 receptor inDrosophilaembryonic retina; those involved in the determination of embryonic axes and in polar cell differentiation, inDrosophila; those involved in the determination of the AB and P cell lineage and in ...
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Quantum Mechanics predicts evolutionary biology
Progress in Biophysics and Molecular Biology, 2018Nowhere are the shortcomings of conventional descriptive biology more evident than in the literature on Quantum Biology. In the on-going effort to apply Quantum Mechanics to evolutionary biology, merging Quantum Mechanics with the fundamentals of evolution as the First Principles of Physiology-namely negentropy, chemiosmosis and homeostasis-offers an ...
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Atherosclerotic lesion mechanics versus biology
Zeitschrift f�r Kardiologie, 2000The world-wide importance of acute vascular syndromes is increasing. Acute events are usually triggered by fibrous cap disruption and subsequent thrombus formation. Histological studies have established specific structural features common among unstable plaques.
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Mechanics, fields and statistical mechanics in developmental biology
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1977Roux explicitly adopted mechanical causality as a necessary explanatory principle in embryology, while Driesch introduced the complementary idea of the morphogenetic field. The present status of these concepts in developmental biology is described, together with recent developments in the formal description of field behaviour.
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Synthetic Biology: A Challenge to Mechanical Explanations in Biology?
Perspectives in Biology and Medicine, 2012In their plans to modify organisms, synthetic biologists have contrasted engineering and tinkering. By drawing this contrast between their endeavors and what has happened during the evolution of organisms by natural selection, they underline the novelty of their projects and justify their ambitions.
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Transposon control mechanisms in telomere biology
Current Opinion in Genetics & Development, 2018The ends of linear eukaryotic chromosomes, telomeres, are elongated by reverse transcriptase activity provided by the enzyme telomerase, or by specialized telomeric retrotransposons. Telomerase and telomeric retrotransposons represent unique examples of structurally different, but evolutionary and functionally related machineries that generate ...
Maria Kordyukova +2 more
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Nitric Oxide, 2012
Nitroxyl (HNO) is the one-electron reduced and protonated congener of NO. It has been reported that HNO has numerous important and therapeutically useful biological properties. Although it has not been demonstrated that HNO is endogenously generated, developing HNO-donors as pharmacological agents has become an area of significant interest.
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Nitroxyl (HNO) is the one-electron reduced and protonated congener of NO. It has been reported that HNO has numerous important and therapeutically useful biological properties. Although it has not been demonstrated that HNO is endogenously generated, developing HNO-donors as pharmacological agents has become an area of significant interest.
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