Results 281 to 290 of about 10,501,738 (419)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Iron and energy metabolic interactions in Treg-mediated immune regulation. [PDF]

Front Immunol
Savagner F, Farge T, Karim Z, Aloulou M.
europepmc   +1 more source

Molecular mechanisms of acetylcholine receptor–lipid interactions: from model membranes to human biology

, 2012
John E. Baenziger, Corrie J.B. daCosta
openalex   +2 more sources

Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects [PDF]

, 2015
Ellen L. Berg, Mark A. Polokoff, Alison O’Mahony, Dat Nguyen, Xitong Li   +4 more
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Advances in Endoplasmic Reticulum Stress Research-Insights from the Special Issue "Endoplasmic Reticulum Stress and Apoptosis". [PDF]

Int J Mol Sci
Lizák B, Kapuy O.
europepmc   +1 more source

Deciphering the pharmacological mechanism of the Chinese formula Huanglian-Jie-Du decoction in the treatment of ischemic stroke using a systems biology-based strategy [PDF]

, 2015
Yanqiong Zhang, Songsong Wang, Weiliang Zhu, Yan Ma, Fangbo Zhang, Rixin Liang, Haiyu Xu, Hongjun Yang   +7 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

The texture-taste connection: Multimodal sensory neurons in fly larvae. [PDF]

PLoS Biol
Vogt K.
europepmc   +1 more source

The Cell and Molecular Biology of Glaucoma: Mechanisms of Retinal Ganglion Cell Death

, 2012
Robert W. Nickells
openalex   +1 more source