Results 281 to 290 of about 2,474,961 (353)

The Japan-UK Synthetic Biology Conference, Spring 2025: Strengthening Global Links to Engineer Biology. [PDF]

ACS Synth Biol
Gorochowski TE, Brockhurst MA, Ceroni F, Iwasaki YW, Yachie N.   +4 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Effect of Maternal Hyperglycemia on Fetal Pancreatic Islet Development. [PDF]

Biology (Basel)
Dias CP, Teixeira Paiva de Moraes MR, Correia Barrence FA, Balbino da Silva CS, Smuckzec B, Ortis F, Zorn TMT.   +6 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Systematic acupuncture explains acupuncture at Baihui (GV20) and Fengchi (GB20) targeting the inflammatory response to regulate migraine. [PDF]

J Tradit Chin Med
Yu M, Meifeng Z, Ju S, Zetong P, Zhixian C, Xiaohua H.   +5 more
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry. [PDF]

PLoS Pathog
Wang K, Eady AN, Amaya I, Stanczak A, Spriggs CC.   +4 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

A physical model links structure and function in the plant immune system. [PDF]

Proc Natl Acad Sci U S A
Weiner BG, Märkle H, Laderman E, Demirjian C, Bergelson J.   +4 more
europepmc   +1 more source

Collagen Fibrillogenesis: A Mechanism of Structural Biology

Journal of Investigative Dermatology, 1986
openaire   +3 more sources