Based on network pharmacology and molecular docking technology to explore the pharmacodynamic components and mechanism of Gynostemmae Pentaphylli Herba reversing Cervical intraepithelial neoplasia. [PDF]
Wang H, Chen Y, Lin T.
europepmc +1 more source
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano+16 more
wiley +1 more source
Editorial: Perivascular niche and stem cell signaling in tooth. [PDF]
Ouchi T, Shimizu E, Li B.
europepmc +1 more source
A Computational Systems Biology Study for Understanding Salt Tolerance Mechanism in Rice
Juexin Wang+5 more
openalex +2 more sources
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley +1 more source
Not just a garbage truck: No-go decay plays a role during embryo development in zebrafish. [PDF]
Plastrik AR, Zaher HS.
europepmc +1 more source
HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang+11 more
wiley +1 more source
Construction of cDNA library of Dalbergia odorifera induced by low temperature stress and screening of low temperature tolerant genes. [PDF]
Li S, An X, Li F, Chen Y, Li X.
europepmc +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo+2 more
wiley +1 more source