Results 141 to 150 of about 2,036,755 (365)

Mobile mechanism scheme design of wheel-legged lunar rover

, 2010
The configuration combination design method of wheel-legged lunar rover was proposed, which regards the mobile mechanism of wheel-legged lunar rover as three sub-configurations: wheel-legged mechanism, suspension and bodywork.
Wang YM(汪永明), Tang WC(汤文成), Yu XL(余晓流), Fan, Tonghua   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dynamic Optimization of Constrained Layer Damping Structure for the Headstock of Machine Tools with Modal Strain Energy Method

Shock and Vibration, 2017
Dynamic stiffness and damping of the headstock, which is a critical component of precision horizontal machining center, are two main factors that influence machining accuracy and surface finish quality. Constrained Layer Damping (CLD) structure is proved
Yakai Xu, Weiguo Gao, Yuhan Yu, Dawei Zhang, Xiangsong Zhao, Yanling Tian, Huaying Cun   +6 more
doaj   +1 more source

Mechanism Design of Health Care Blockchain System Token Economy: Development Study Based on Simulated Real-World Scenarios. [PDF]

J Med Internet Res, 2021
Jung SY, Kim T, Hwang HJ, Hong K.
europepmc   +1 more source

A mechanism for multiple goods and interdependent valuations

, 2004
This paper reports on the design of an auction mechanism for allocating multiple goods when the buyers have interdependent valuations. We cast the problem as a multi-agent system consisting of selfish, rational agents and develop an auction mechanism ...
Dash, R. K., Jennings, N. R., Rogers, A.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhancing telesurgical safety with predictive digital twin synchronization: a framework for latency compensation in robotic surgery

npj Digital Medicine
This study addresses the critical challenge of master-slave latency in robot-assisted telesurgery by introducing a Digital Twin Visual Assistance (DTVA) system.
Hang Yuan, Junjie Li, Bo Guan, Guangdi Chu, Wei Jiao, Hongzhi Zheng, Xingchi Liu, Jianchang Zhao, Jinhua Li, Jianmin Li, Xuecheng Yang, Haitao Niu   +11 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Novel Flexible Endomicroscopic Scanning Instrument with Visual Servoing Control

Advanced Intelligent Systems
Optical biopsy using probe‐based confocal laser endomicroscopy (pCLE) and optical coherence tomography (OCT) technologies performs in vivo tissue scanning of organ surfaces and plays a crucial role in early cancer diagnosis.
Xingfeng Xu, Chengyu Zhang, Chi Zhang, Siyang Zuo   +3 more
doaj   +1 more source

Dynamic Error Compensation for Ball Screw Feed Drive Systems Based on Prediction Model

Machines
The dynamic error is the dominant factor affecting multi-axis CNC machining accuracy. Predicting and compensating for dynamic errors is vital in high-speed machining.
Hongda Liu, Yonghao Guo, Jiaming Liu, Wentie Niu   +3 more
doaj   +1 more source