Results 131 to 140 of about 2,036,755 (365)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mechanism design and analysis of a foot massage robot

, 2013
Combining the traditional Chinese-medicine theory and the modern robot technology, a new type of massage robot that can accurately locate the acupuncture points and implement the acupuncture point-matching treaatment has been proposed.
Jiang Y(姜勇), Chang Y(常勇), Xiao SY(肖时雨), Wang HG(王洪光), Cong PT(丛培田), Ma, DongHua   +5 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Author Correction: The effects of text direction of different text lengths on Chinese reading

Scientific Reports, 2023
Yanqun Huang, Yifan Dong, Zhaojun Jiang, Peng Zhang, Jutao Li, Junyu Yang   +5 more
doaj   +1 more source

Tropical Geometry and Mechanism Design [PDF]

, 2016
Robert Alexander Crowell, Ngoc Mai Tran
openalex   +1 more source

What mechanism design helps to realize the innovation function of maker-spaces: A qualitative comparative analysis based on fuzzy sets. [PDF]

PLoS One, 2022
Zheng J, Shi L, Jiang T.
europepmc   +1 more source

A Compression-Driven Test Access Mechanism Design Approach

, 2004
Driven by the industrial need for low-cost test methodologies, the academic community and the industry alike have put forth a number of efficient test data compression (TDC) methods. In addition, the need for core-based System-on-a-Chip (SoC) test led to
Gonciari, Paul Theo, Al-Hashimi, Bashir
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Research on Product Conceptual Design Scheme Configurations from a Designer–User Conflict Perspective

Applied Sciences
In the context of rapid product iteration, design conflicts arise from discrepancies in designers’ understanding of user needs, influenced by subjective preferences, behavioural stances, and other factors.
Hongyu Shao, Sizhe Pan, Yufei Song, Quanfu Li   +3 more
doaj   +1 more source

Prediction of Dynamic Milling Stability considering Time Variation of Deflection and Dynamic Characteristics in Thin-Walled Component Milling Process

Shock and Vibration, 2016
The milling stability of thin-walled component is an important problem in the aviation manufacturing industry. The milling stability is influenced by both deflection characteristic and dynamic characteristic of workpiece.
Li Zhang, Weiguo Gao, Dawei Zhang, Yanling Tian   +3 more
doaj   +1 more source