Results 171 to 180 of about 2,036,755 (365)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Matching IoT Devices to the Fog Service Providers: A Mechanism Design Perspective. [PDF]

open access: yesSensors (Basel), 2020
Bandyopadhyay A   +5 more
europepmc   +1 more source

The application of self-adaptive design in improvement of the restoring strand operation mechanism

open access: yes, 2014
Aiming at solving the problem that the existing restoring strand operation mechanism cannot realize self-adaption to the variation of position and shape of transmission lines, a method for self-adaptive mechanism design is introduced and summarized to ...
Liu ZS(刘章石)
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A study of an improved cutting mechanism of composite materials using novel design of diamond micro-core drills

open access: hybrid, 2014
Paul Butler‐Smith   +6 more
openalex   +1 more source

"Detail-Free Mechanism Design in Twice Iterative Dominance: Large Economies" [PDF]

open access: yes
This paper investigates unique implementation in large economies with incomplete information and interdependent values; we degenerate the common knowledge assumptions and assume that a central planner is unaware of the specifications of an environment ...
Hitoshi Matsushima
core  

Strategies and methods for robust design in the early phases of product development in precision engineering [PDF]

open access: yes
The early phases of product development are critical for ensuring market success, as the essential decisions for the entire product life cycle are made during this phase.
Brix, Torsten   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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