Results 181 to 190 of about 2,036,755 (365)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Contracting with a Mechanism Designer
This paper explores the economic interactions within modern crowdsourcing markets. In these markets, employers issue requests for tasks, platforms facilitate the recruitment of crowd workers, and workers complete tasks for monetary rewards. Recognizing that these roles serve distinct functions within the ecosystem, we introduce a three-party model that
Tian Bai +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Optimal Multi-Dimensional Mechanism Design: Reducing Revenue to Welfare Maximization [PDF]
, 2012 Yang Cai +2 more
openalex +1 more source
Scalable Mechanism Design for the Procurement of Services with Uncertain Durations
, 2010 In this paper, we study a service procurement problem with uncertainty as to whether service providers are capable of completing a given task within a specified deadline. This type of setting is often encountered in large and dynamic multi-agent systems,
Larson, Kate +5 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Research on Design Theory of Cam Type Torsional Transmission Mechanism [PDF]
, 2016 Fan-bi WANG, Tieshan Zhang, Mingsong Li
openalex +1 more source
Applying Scenarios in the context of Specific User Design: Surgeon as an Expert User, and Design for Handicapped Children. [PDF]
, 2009 Organised by: Cranfield UniversityIn the context of specific user (surgery or handicap domain), the list of requirements is especially difficult to establish.
Rasoulifar, Rahi +5 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
3106 Development of Compliant Mechanisms Based on Optimum Design
, 2007 Ryo Horiuchi +5 more
openalex +1 more source