Results 181 to 190 of about 4,576,095 (337)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A review of wrist mechanism design and the application in gastrointestinal minimally invasive surgery of multi-degree-of-freedom surgical laparoscopic instruments. [PDF]

Surg Endosc
Tu Y, Jiang J, Huang J, Sui J, Yang S.
europepmc   +1 more source

Current Total Knee Designs: Does Baseplate Roughness or Locking Mechanism Design Affect Polyethylene Backside Wear? [PDF]

Clin Orthop Relat Res, 2017
Sisko ZW, Teeter MG, Lanting BA, Howard JL, McCalden RW, Naudie DD, MacDonald SJ, Vasarhelyi EM.   +7 more
europepmc   +1 more source

Research on Top-Down design of launcher fairing mechanism equipped on Air-to-Ground missile carried by UAV

Yu Pang, Zeyang Li, Qi Zhang, Yu Lei, Yang Li, Yangyang Xu, Ruiqing Liu   +6 more
openalex   +1 more source

Design Of A Mobile Agents Based Solution To Distributional Management Of Computer Networks, Taking Into Account The Security Mechanisms

, 2017
S. Bahrami
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pricing Mechanism Design for Centralized Pollutant Treatment with SME Alliances. [PDF]

Int J Environ Res Public Health, 2016
Li Y, Huang B, Tao F.
europepmc   +1 more source

Inverse optimization design of sugarcane seeding mechanism based on approximate multi-position and posture

Chen Qing-Li, Jiaodi Liu, Xu Hongzhen, Yong Hua, Xiaoman Wu   +4 more
openalex   +1 more source

Design of Tendon-Driven Mechanism Using Geometrical Condition [PDF]

, 2020
Takashi Takuma
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source