Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Online Auction Design Using Distribution-Free Uncertainty Quantification with Applications to E-Commerce. [PDF]
Han J, Dai X.
europepmc +1 more source
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Finger Unit Design for Hybrid-Driven Dexterous Hands. [PDF]
Deng C +5 more
europepmc +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Development of a Dual Photoacoustic-Ultrasound Imaging System: Current Status and Future Perspectives. [PDF]
Pham VH, Nguyen Van T.
europepmc +1 more source
Design and simulation of a solar array deployment mechanism for a small satellite using implicit time-stepping. [PDF]
Saad GB, Desoki AR, Kassab M.
europepmc +1 more source
Research on a Hexapod Hybrid Robot with Wheel-Legged Locomotion and Bio-Inspired Jumping for Lunar Extreme-Terrain Exploration. [PDF]
Han L +6 more
europepmc +1 more source
Research on the path of social psychological collaborative education in colleges and universities driven by the dynamic reward and punishment mechanism of the government. [PDF]
Guo J, Gao Y, Tang F.
europepmc +1 more source

