Results 111 to 120 of about 1,876,013 (306)

The Quantitative Research of Interaction between Key Parameters and the Effects on Mechanical Property in FDM

Advances in Materials Science and Engineering, 2017
The central composite design (CCD) experiment is conducted to evaluate the interaction between parameters and the effect on mechanical property. The layer thickness, deposition velocity, and air gap are considered as the key factors.
Hongbin Li, Taiyong Wang, Zhiqiang Yu
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Research on Product Conceptual Design Scheme Configurations from a Designer–User Conflict Perspective

Applied Sciences
In the context of rapid product iteration, design conflicts arise from discrepancies in designers’ understanding of user needs, influenced by subjective preferences, behavioural stances, and other factors.
Hongyu Shao, Sizhe Pan, Yufei Song, Quanfu Li   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An optimal Voting System when Voting is costly [PDF]

We consider the design of an optimal voting system when voting is costly. For a private values model with two alternatives we show the optimality of a voting system that combines three elements: (i) there is an arbitrarily chosen default decision and non-
Bognar, Katalin, Börgers, Tilman, Meyer-ter-Vehn, Moritz   +2 more
core   +1 more source

Envy Freedom and Prior-free Mechanism Design [PDF]

, 2012
We consider the provision of an abstract service to single-dimensional agents. Our model includes position auctions, single-minded combinatorial auctions, and constrained matching markets.
Devanur, Nikhil R., Hartline, Jason D., Yan, Qiqi   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Novel Flexible Endomicroscopic Scanning Instrument with Visual Servoing Control

Advanced Intelligent Systems
Optical biopsy using probe‐based confocal laser endomicroscopy (pCLE) and optical coherence tomography (OCT) technologies performs in vivo tissue scanning of organ surfaces and plays a crucial role in early cancer diagnosis.
Xingfeng Xu, Chengyu Zhang, Chi Zhang, Siyang Zuo   +3 more
doaj   +1 more source

Duality theory for optimal mechanism design

, 2016
In this work we present a general duality-theory framework for revenue maximization in additive Bayesian auctions involving multiple items and many bidders whose values for the goods follow arbitrary continuous joint distributions over some multi-dimensional real interval.
openaire   +1 more source

Essays in game theory and mechanism design

, 2023
Aquesta tesi pretén comprendre les negociacions sobre el comportament que els agents tindran en un joc i, per separat, una implementació robusta. El capítol 1 examina els acords vinculants que resulten d’una negociació sobre què jugar en un joc, proposant un protocol de negociació i caracteritzant els resultats de l’acord mitjanant un perfeccionament ...
openaire   +1 more source