Results 351 to 360 of about 4,146,035 (404)
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Journal of Pharmacy and Science, 1963
Theoretically expected rates of release of solid drugs incorporated into solid matrices have been derived for several model systems. Mathematical relations have been obtained for cases (a) where the drug particles are dispersed in a homogeneous, uniform ...
T. Higuchi
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Theoretically expected rates of release of solid drugs incorporated into solid matrices have been derived for several model systems. Mathematical relations have been obtained for cases (a) where the drug particles are dispersed in a homogeneous, uniform ...
T. Higuchi
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Colchicine Pharmacokinetics and Mechanism of Action.
Current pharmaceutical design, 2018Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family Colchicum autumnale, sometimes called the "autumn crocus". It is predominantly metabolized in the gastrointestinal tract.
C. Angelidis +7 more
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Synthetic phenolic antioxidants: Metabolism, hazards and mechanism of action.
Food Chemistry, 2021Xiaoqing Xu +8 more
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siRNA: Mechanism of action, challenges, and therapeutic approaches.
European Journal of Pharmacology, 2021W. Alshaer +7 more
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Neurobiology of depression and mechanism of action of depression treatments.
Journal of Clinical Psychiatry, 2016Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), may alleviate depressive symptoms but also leave residual symptoms. The mechanism of action of SSRIs increases serotonin (5-HT) activity but decreases norepinephrine (NE) and ...
P. Blier
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Mechanism of Action of Somatostatin
Hormone Research, 1988The chain of events leading to the manifestation of the biological action of somatostatin are described. Internalization is mediated by cytoskeletal proteins in the presence of calmodulin. Transduction of the somatostatin message at the membrane level takes place through inhibition of cyclic AMP accumulation and blockade of cytosol calcium increases ...
L. Birnbaumer +3 more
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Mechanism of action of mitoxantrone
Neurology, 2004Mitoxantrone, a synthetic anthracenedione, was developed in the 1980s as a doxorubicin analogue in a program to find a cytotoxic agent with decreased cardiotoxicity compared with doxorubicin. It was approved by the FDA in 1987 for the treatment of adult acute myeloid leukemia and in 1996 for symptomatic hormone-refractory prostate cancer.
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Thalidomide: Mechanisms of Action
International Reviews of Immunology, 2008The classification of thalidomide as an orphan drug with anti-inflammatory actions has led to its off-label use in conditions refractory to other medications. Although the observed clinical effects of thalidomide suggest it to have immunomodulatory capabilities, the mechanism of action is unclear.
Taraneh Paravar, Delphine J. Lee
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Philosophical Studies, 1968
IN The Explanation of Behavior, Charles Taylor asks whether "the concepts we use in our everyday account [of human behavior] can be applied without change of meaning to beings whose behavior could be explained by nonteleological laws" (p. 40).1 Taylor's answer is no. He concludes that if there were an adequate non-teleological theory of human behavior,
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IN The Explanation of Behavior, Charles Taylor asks whether "the concepts we use in our everyday account [of human behavior] can be applied without change of meaning to beings whose behavior could be explained by nonteleological laws" (p. 40).1 Taylor's answer is no. He concludes that if there were an adequate non-teleological theory of human behavior,
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Metabolism, 1972
Abstract ACTH regulates both the differentiated function (steroidogenesis) and the growth and replicative potential of the adrenal cortex. Cyclic AMP (cAMP) serves as the mediator of ACTH action within the cell. The binding of cAMP to its specific receptor activates a protein phosphokinase enzyme with resultant phosphorylation and altered function of
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Abstract ACTH regulates both the differentiated function (steroidogenesis) and the growth and replicative potential of the adrenal cortex. Cyclic AMP (cAMP) serves as the mediator of ACTH action within the cell. The binding of cAMP to its specific receptor activates a protein phosphokinase enzyme with resultant phosphorylation and altered function of
openaire +3 more sources