Results 51 to 60 of about 10,815 (305)
Strategic planning in the mechanism of public administration: innovations in legal regulation
Административное и муниципальное право, 2022 The subject of this article is the study of a new stage in the development of state policy in the field of strategic planning. The object of the study was the social relations developing in the sphere of strategic planning implementation in Russia and its regulatory and legal regulation.Methods of synthesis and analysis of literary and documentary ...
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Actual Problems of Russian Law, 2022 The study of the mechanism of administrative and legal regulation in the field of higher education is impossible without identifying the constitutional and legal foundations of its formation. The special significance of this topic is determined by the amendment to the Constitution of the Russian Federation that defines in a new way the distribution of ...
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Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
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Сибирское юридическое обозрение, 2017 In the mechanism of legal regulation of administrative responsibility for violations of the customs legislation of the Customs Union of the Eurasian Economic Union there are legal gaps, in particular, in theory and practice, the imposition of ...
Margarita N. Kobzar-Frolova
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G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
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Administrative and legal regulation of innovation: Tutorial
, 2020 Адміністративно-правове регулювання інноваційної діяльності: навчальний посібник / Ковалів М. В., Ортинська Н. В., Хомишин І. Ю., Єсімов С. С., Скочиляс-Павлів О. В., Сидор М. Я., Скриньковський Р. М. - Львів: НУ «Львівська політехніка», 2020.
Sydor, M.Ya. +5 more
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Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
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REGULATION URGENCY CONCERNING ADMINISTRATIVE SANCTION GUIDELINES IN SPACE ADMINISTRATION
Jurnal Pembaharuan Hukum, 2019 The spatial development can be supported by sustainable development, efforts are needed to divert space through the imposition of sanctions on administration in the spatial field.
Rakhmat Bowo Suharto
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The state of fundamental legal rights in Australia [PDF]
, 2014 Executive summary: This report demonstrates that a serious problem exists with respect to fundamental legal rights in Australian law. Our research has focussed on the extent to which four such fundamental legal rights are abrogated in current acts of the
Simon Breheny
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Advanced Science, EarlyView.ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
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