Results 71 to 80 of about 10,815 (305)

Systematization of legal regulation as a mechanism of public administration and regulatory assessment

E3S Web of Conferences
Introduction. In modern conditions of the development of legal relations, legal regulation seems to be insufficiently effective due to a number of reasons: the lack of a unified approach to public administration, an excessive number of legislative prescriptions, the disintegration of legal regulation elements, inconsistency of regulatory requirements,
Alekhina E.S., Nadtoka S.V.
openaire   +2 more sources

Legality of normative legal acts as an element of the mechanism of administrative and legal regulation

, 2019
Єсімов С.С. Законність нормативно-правових актів як елемент механізму адміністративно-правого регулювання / Єсімов С.С., Малець М.Р., Стельмащук П.Я. // Наше право. - 2019. - № 1. - С.
Єсімов, С.С., Yesimov, S.S.
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Mechanism of administrative legal regulation and its constituent elements

Uzhhorod National University Herald. Series: Law
It is indicated that a mandatory prerequisite for a high level of fundamental scientific research on issues of administrative law, as well as the possibility of the science of administrative law to serve as a progressive theoretical and legal basis for the understanding and improvement of phenomena and processes that occur during the implementation of ...
openaire   +3 more sources

Some questions of state regulation in the sphere Healthcare of the Republic Kazakhstan

Хабаршы. Заң сериясы, 2015
The article considers the issues of state regulation in the healthcare sector. We consider the legal framework in the field of health care associated with changes in the current legislation. Features of legal maintenance of public relations in
Tuyakbayeva N.S., Erkin D.M.
doaj  

The actual aspects of the prevention of the illegal beneficial interest to become and the administrative-legal regulation of the tax system of the Russian Federation

, 2020
The author creates a model (pyramid) of the causality which occurs under the tax legal regulatory mechanism. There is an analysis of the details of implementation of a risk-based approach by the Russian tax authorities with use of innovative hardware ...
Novoselova, Maria A.
core   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

ADMINISTRATIVE RESPONSIBILITY (THE CONSTITUTIONAL DESIGN)

Гуманитарные и юридические исследования, 2021
The article studies basic elements of the constitutional design of the administrative responsibility: proportionality of the restriction of citizens' rights and freedoms to the constitutionally signiicant interests and goals; presence of guilt as an ...
I. V. Maximov
doaj  

The ways to improve state regulation of land turnover which are in a government and municipal property in Ukraine

Aspekti Publìčnogo Upravlìnnâ, 2016
After comprehensive scientific exploration the ways of improvement of state regulation of land turnover which are in a government and state municipal property in Ukraine have been identified.
S. A. Serdyuk
doaj   +1 more source