Results 71 to 80 of about 13,212 (299)

Systematization of legal regulation as a mechanism of public administration and regulatory assessment

E3S Web of Conferences
Introduction. In modern conditions of the development of legal relations, legal regulation seems to be insufficiently effective due to a number of reasons: the lack of a unified approach to public administration, an excessive number of legislative prescriptions, the disintegration of legal regulation elements, inconsistency of regulatory requirements,
Alekhina E.S., Nadtoka S.V.
openaire   +2 more sources

The mechanism of administrative and legal regulation of social relations in the conditions of martial law

Alʹmanah prava, 2022
The article examines the problems of the mechanism of administrative and legal regulation of social relations in the conditions of martial law. Attention is paid to the current state of research in the theory of law and inиadministrative law of this phenomenon, and it is concluded that the emphasis on the instrumental aspect of the mechanism of ...
openaire   +1 more source

Administrative and Legal Regulation: Theoretical Approaches to Definition

У публікації проведено теоретико-правовий аналіз поняття «адміністративно-правове регулювання» та його співвідношення зі спорідненими категоріями «механізм адміністративно-правового регулювання» та «адміністративно-правове забезпечення».
Buhaichuk, Kostiantyn, Бугайчук, Костянтин   +1 more
core   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

ADMINISTRATIVE AND LEGAL REGULATION OF THE USE OF INFORMATION TECHNOLOGIES FOR THE DEVELOPMENT OF THE NATIONAL ECONOMY

Baltic Journal of Economic Studies
The scholarly publication examines administrative and legal regulation of the use of information technologies in the development of the national economy. It is noted that contemporary information technologies have the potential substantially improve the
Mykhailo Serebro, Natalia Blazhivska, Valeriia Chernyshova   +2 more
doaj   +1 more source

Administrative Constitutionalism in the Legal mechanism of Public Administration in Modern Russia

The monograph presents the characteristics of modern theoretical and applied problems of legal regulation in the context of the formation of the doctrine of administrative constitutionalism.
Roman Nagornyh
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source