Results 111 to 120 of about 202,689,495 (297)

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Mechanism of administrative and legal regulation in the banking sphere

, 2012
Досліджуються поняття механізму адміністративно-правового регулювання у сфері банківської діяльності та його складові: правовий статус НБУ, його нормативно правові та правозастосовні акти, зміст адміністративно-правових відносин у зазначеній сфері ...
Чернов, М.М.
core  

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

Rethinking Cochlear Implants: The Need for Precise Temporal Coding

Advanced Science, EarlyView.
Spatial hearing relies on sensitivity to interaural temporal cues, but this sensitivity is often poorly developed in patients with cochlear implants, particularly those with early‐onset hearing loss. Rats with cochlear implants, however, demonstrate excellent temporal sensitivity, suggesting that this limitation is not inevitable.
Nicole Rosskothen‐Kuhl, Jan W. H. Schnupp   +1 more
wiley   +1 more source

Solicitors' CPD: time to change from regulatory stick to regulatory carrot [PDF]

, 2011
Summary: The legal professions are agreed on the need for some form of continuing professional development (“CPD”) after qualification. What is less clear is the intention of such frameworks and in contrast to other forms of more diffuse learning in the ...
Ching, J
core  

Professor V.V. Lazarev’s theoretical and legal views on the forms of judicial regulation in modern Russia

Известия высших учебных заведений. Поволжский регион: Общественные науки
Background. The scientific legacy of Professor V.V. Lazarev has not lost its relevance for modern Russian science. His theoretical and practical research in the field of legal gaps, their identification and elimination, the mechanism of legal regulation ...
Pavel A. Guk
doaj   +1 more source

CD34+ Progenitors Promote Ageing‐Associated Valve Sclerosis through the PDGFR–JNK–JUNB Pathway

Advanced Science, EarlyView.
In age‐related aortic valve sclerosis, non‐bone marrow CD34+ progenitor valvular interstitial cells (VICs) undergo transdifferentiation into periostin+ myofibroblast‐like VICs via the PDGFR‐JNK‐JUNB axis, driving leaflet thickening and fibrosis. Ablating non‐bone marrow CD34+ cells attenuates this remodeling.
Xiaoping Yang, Hong Wu, Guoqiang Ren, Yuesheng Zhang, Zuoshi Wen, Pengwei Zhu, Zhangquan Ying, Liujun Jiang, Tingting Tao, Bohuan Zhang, Linwen Zhu, Han Wang, Han Zhang, Qingbo Xu, Jun Cheng, Honghua Ye   +15 more
wiley   +1 more source

. Механізм правового регулювання та правова система: співвідношення правових категорій.The mechanism of legal regulation and the legal system: ratio of the legal categories

, 2008
Кривицький Ю. Механізм правового регулювання та правова система: співвідношення правових категорій / Ю. Кривицький // Підприємництво, господарство і право. – 2008. – № 8. – С.
Кривицький, Юрій Віталійович, Kryvytskyi, Yurii   +1 more
core  

Assessing Photovoltaic Recycling Capacities and Policy Gaps in the European Union

Advanced Energy and Sustainability Research, EarlyView.
This study maps photovoltaic recycling capacity in the EU and key global regions, highlighting gaps between growing waste volumes and available infrastructure. It combines survey insights and policy analysis to identify recycling bottlenecks and offers recommendations to boost circularity in the solar sector.
Nieves Espinosa, Silvia Bobba, Cynthia E. L. Latunussa, Enrica Leccisi   +3 more
wiley   +1 more source