Results 51 to 60 of about 169,186,284 (259)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The never-ending story of public administration reform in Slovenia (from 1991 to further development) [PDF]

, 2014
In Slovenia, the public administration reform has been a systematic task since 1996 when the government adopted the strategy of transformation of public administration due to Slovenia becoming a full member of EU.
Kovač, Polona
core   +1 more source

Survey of the Key Methods of Improving Public Trust to Government [PDF]

Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2014
SurveyoftheKeyMethodsofImprovingPublicTrusttoGovernment   Hasan Danaee Fard* - Ali Reza Hasanzadeh** - Somayeh Nasroallahi***   (Received: 2014/April/17 – Accept: 2014/Octobr/27)   Abstract   Public Trust is considered as a strategic capital of any ...
Hassan Danaee fard, Ali Reza Hassan zadeh, Somayeh Nasrollahi   +2 more
doaj  

Governmental policy capacity and policy work in a small place: Reflections on perceptions of civil servants in Prince Edward Island, Canada from a practitioner in the field

JPAS (Journal of Public Administration Studies), 2020
The body of public administration literature is missing contributions from practitioners in the field. Emic or insider-led studies of public administration can act as powerful mechanisms to generate new knowledge.
Bobby Thomas Robert Cameron
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The Constitution of Ireland 1937-1987 [PDF]

, 1988
A Constitution defines the political institutions of a state and sets boundaries to its authority. In this it shapes the form of living together of a people.
Litton, Frank, Institute of Public Administration (IPA)   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Job search, Justice or public interest?, Economics and health policy, Homelesses in Northern Ireland, Backbench committees.

, 1988
Administration is published four times a year. It is the journal of the . Institute of Public Administration in Ireland. The views expressed in it are the The views of the contributors are not necessarily those of the Institute.
Litton, Frank, Institute of Public Administration (IPA)   +1 more
core  

Chile: public administration after the New Public Management

, 2021
NPM-style public sector reform policies were implemented in the Chilean public administration in the 90s and in the first years of the new century.
Pliscoff, Cristian, Cristian Pliscoff
core   +1 more source