Results 121 to 130 of about 22,796,869 (307)
Química Nova, 1999 In organic synthesis, lipases are the most frequently used biocatalysts. They are efficient stereoselective catalysts in the kinetic resolution of a wide variety of chiral compounds.
Costa Valentim Emilio Uberti +1 more
doaj
Frontiers in ImmunologyIntroductionThe COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop interoperable ...
Anna Niarakis +108 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Revista Fuentes El Reventón Energético, 2011 he steam injection in horizontal wells has great applicability to heavy oil reservoirs. However, one of the challenges of this technology is the prediction of the profiles of pressure, temperature and vapor quality along the well.
Gustavo Rojas Sosa +1 more
doaj +2 more sources
Revista Facultad de Ingeniería Universidad de Antioquia, 2018 Bioprocesses productivity is a compromise between two conflicting objectives, maximization of biomass growth rate and minimization of substrate consumption.
Adriana Patricia Villegas-Quiceño +4 more
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Fast inference in nonlinear dynamical systems using gradient matching [PDF]
, 2016 Parameter inference in mechanistic models of coupled differential equations is a topical problem. We propose a new method based on kernel ridge regression and gradient matching, and an objective function that simultaneously encourages goodness of ...
Filippone, Maurizio +3 more
core
Does "model-free" forecasting really outperform the "true" model? A reply to Perretti et al
, 2013 Estimating population models from uncertain observations is an important problem in ecology. Perretti et al. observed that standard Bayesian state-space solutions to this problem may provide biased parameter estimates when the underlying dynamics are ...
Dormann, Carsten F., Hartig, Florian
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source