Results 101 to 110 of about 7,721,638 (300)

Image2_MEMMAL: A tool for expanding large-scale mechanistic models with machine learned associations and big datasets.TIF

, 2023
Computational models that can explain and predict complex sub-cellular, cellular, and tissue-level drug response mechanisms could speed drug discovery and prioritize patient-specific treatments (i.e., precision medicine). Some models are mechanistic with
Cemal Erdem (11054081), Marc R. Birtwistle (10825523)   +1 more
core   +1 more source

ESTUDIO COMPARATIVO ENTRE CORRELACIONES EMPÍRICAS Y MODELOS MECANÍSTICOS PARA FLUJO MULTIFÁSICO EN POZOS HORIZONTALES DE INYECCIÓN DE VAPOR

Revista Fuentes El Reventón Energético, 2011
he steam injection in horizontal wells has great applicability to heavy oil reservoirs. However, one of the challenges of this technology is the prediction of the profiles of pressure, temperature and vapor quality along the well.
Gustavo Rojas Sosa, Manuel Cabarcas Simancas   +1 more
doaj   +2 more sources

Effects of climate change on a nocturnal gecko: an integrative analysis

Frontiers in Amphibian and Reptile Science
IntroductionClimate change poses a major threat to biodiversity, especially for ectotherms whose physiology is tightly coupled to environmental conditions.
Ticiane de Lima Costa, Arinos de Oliveira Serpa, Arthur Sena, Bruno Araújo de Souza, Gabriel Henrique de Oliveira Caetano, Heitor Campos de Sousa, Júlio Miguel Alvarenga da Silva, Leandro Braga Godinho, Luisa Maria Diele-Viegas, Luisa Maria Diele-Viegas, Naiane Arantes Silva, Vitor Hugo Cavalcante, Guarino Rinaldi Colli   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bridging paradigms : hybrid mechanistic-discriminative predictive models

, 2013
Many disease processes are extremely complex and characterized by multiple stochastic processes interacting simultaneously. Current analytical approaches have included mechanistic models and machine learning (ML), which are often treated as orthogonal ...
Tsaneva-Atansaova, Krasimira, Tiffin, Paul A., Harte, J, Díaz-Zuccarini, Vanessa, Tiffin, Paul A, Doyle, O, Doyle, Orla M, Harte, James M., Tsaneva-Atanasova, K, Doyle, Orla M., Harte, J., Diaz-Zuccarini, V, Tiffin, P, Díaz-Zuccarini, V., Tino, Peter, Doyle, O.M., Tsaneva-Atansaova, K., Tiffin, P.A., Tino, P., Tino, P, Harte, James   +20 more
core   +1 more source

Accelerating cardiovascular digital twin creation using precomputed virtual populations as Bayesian priors

Frontiers in Physiology
IntroductionMechanistic lumped-parameter models of the cardiovascular system can provide insight into underlying physiological processes that cannot be measured directly.
Iris L. Shelly, Jon N. Peterson, Giulia Cornali, Jennifer Rohrs, Patrick E. Gelbach, Joe Alexander   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A Comprehensive Framework for Computational Neuroscience: Exploring Descriptive, Mechanistic, and Interpretive Models with Analysis [PDF]

, 2023
This paper introduces a groundbreaking framework for computational neuroscience, uniting Descriptive, Mechanistic, and Interpretive models. Tailored to unravel the complexities of the brain, our framework categorizes and establishes a dynamic platform ...
Anirudh Sowrirajan, et al.
core