Results 121 to 130 of about 7,721,638 (300)

Mechanistic Modeling in Biosystem Engineering: A Review on Mechanistic Models of Calcium Metabolism

Food Engineering Progress, 2013
Calcium is an essential nutrient generally obtained from dietary foods. However, its metabolism is a complex biological network requiring an effective analytical tool. In this review, a few notable calcium mechanistic models are assessed, emphasizing the power of mechanistic modeling in analyzing biological systems because no publication has reviewed
Wang-Hee Lee, Byoung-Kwan Cho
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

Frontiers in Systems Biology
Both machine learning and mechanistic modelling approaches have been used independently with great success in systems biology. Machine learning excels in deriving statistical relationships and quantitative prediction from data, while mechanistic ...
Ben Noordijk, Ben Noordijk, Monica L. Garcia Gomez, Monica L. Garcia Gomez, Kirsten H. W. J. ten Tusscher, Kirsten H. W. J. ten Tusscher, Dick de Ridder, Dick de Ridder, Aalt D. J. van Dijk, Aalt D. J. van Dijk, Robert W. Smith   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Feed additives for methane mitigation: Modeling the impact of feed additives on enteric methane emission of ruminants—Approaches and recommendations

Journal of Dairy Science
: Over the past decade, there has been considerable attention on mitigating enteric methane (CH4) emissions from ruminants through the utilization of antimethanogenic feed additives (AMFA).
Jan Dijkstra, André Bannink, Guilhermo F.S. Congio, Jennifer L. Ellis, Maguy Eugène, Florencia Garcia, Mutian Niu, Ronaldo E. Vibart, David R. Yáñez-Ruiz, Ermias Kebreab   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Predictive and mechanistic multivariate linear regression models for reaction development

, 2018
The utilization of physical organic molecular descriptors for the quantitative description of reaction outcomes in multivariate linear regression models is demonstrated as an effective tool for a priori prediction and mechanistic interrogation.
Celine B. Santiago, Matthew S. Sigman, Jing-Yao Guo   +2 more
core   +1 more source

Climate change may improve physiological suitability for three widespread Mexican snakes

Frontiers in Amphibian and Reptile Science
IntroductionThermal tolerance and performance breadth can define the suitable areas where reptiles can survive and perform at an optimal physiological level.
Ricardo Figueroa-Huitrón, Ricardo Figueroa-Huitrón, Hibraim Adán Pérez-Mendoza   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mechanistic Modeling of Rotating Algal Biofilms

Biotechnology and Bioengineering
ABSTRACT Biofilm‐based microalgal cultivation systems have emerged as a promising alternative to conventional suspended growth methods, offering improved light utilization and biomass productivity. Among these, Rotating Algal Biofilm (RAB) systems are particularly advantageous by subjecting cells to short periodic light/dark (L/D ...
Gao, Yan, Perré, Patrick, Fierro, Ignacio, Lopes, Filipa, Bernard, Olivier   +4 more
openaire   +3 more sources