Results 161 to 170 of about 11,335 (213)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

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Mechanistic Model of Gravitation

Lobachevskii Journal of Mathematics, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Belov, P. A., Lurie, S. A.
openaire   +1 more source

A mechanistic model for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
openaire   +2 more sources

Mechanistic Models for Myelosuppression

Investigational New Drugs, 2003
As myelosuppression is the dose-limiting toxicity for most chemotherapeutic drugs, modelers attempt to find relationships between drug and toxicity to optimize treatment. Mechanistic models, i.e. models based on physiology and pharmacology, are preferable over empirical models, as prior information can be utilized and as they generally are more ...
Lena E, Friberg, Mats O, Karlsson
openaire   +2 more sources

The art of mechanistic modeling in biology

Nature Computational Science, 2022
A combination of experimental evaluation with computational modeling sheds light on how aging and limited lifespan influence population dynamics.
Ata Kalirad, Ralf J. Sommer
openaire   +3 more sources

A Mechanistic Model for Partial Preferences

Theoretical Population Biology, 2000
Classic prey optimal foraging model assumes that individual predators are globally omniscient; that is, they have exact knowledge of prey population densities in the environment. This study examines a spatially explicit individual-based model of a one-predator two-prey system where individual predators are assumed to be omniscient only locally, i.e ...
Berec, Luděk, Křivan, Vlastimil
openaire   +2 more sources

A mechanistic model of a PDGFRα+ cell

Journal of Theoretical Biology, 2016
A novel platelet-derived growth factor receptor alpha-positive cell (PDGFRα(+)) has recently been identified as part of the purinergic inhibitory neural control mechanism in the gastrointestinal (GI) tract. The mechanism through which PDGFRα(+) cells mediate GI muscle relaxation has been found to be associated with the purine receptors P2Y1 and apamin ...
Jing Wui, Yeoh, Alberto, Corrias, Martin L, Buist   +2 more
openaire   +2 more sources

A mechanistic model of plasma filtration

Medical Engineering & Physics, 1998
A model describing the sieving and transmembrane pressure behavior of plasma filtration is developed and numerically simulated. The model assumes a mechanistic criteria for particle passage through a membrane with cylindrical pores. The initial pore diameter distribution and porosity are assumed to be known.
C A, Fernandez, G M, Saidel, P S, Malchesky, M, Zborowski   +3 more
openaire   +2 more sources