Results 161 to 170 of about 869,043 (286)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage. [PDF]

Elife
Huang Z, Luo S, Wang Z, Zhang Z, Jiang B, Nie Q, Zhang J.   +6 more
europepmc   +1 more source

Towards mechanistic models of mutational effects: Deep learning on Alzheimer's Aβ peptide. [PDF]

Comput Struct Biotechnol J, 2023
Wang B, Razavi S, Gamazon ER.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase. [PDF]

Nat Commun
Nagae F, Murata Y, Yamauchi M, Takada S, Terakawa T.   +4 more
europepmc   +1 more source

Mechanistic models of Rift Valley fever virus transmission: A systematic review. [PDF]

PLoS Negl Trop Dis, 2022
Cecilia H, Drouin A, Métras R, Balenghien T, Durand B, Chevalier V, Ezanno P.   +6 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mechanistic models of humoral kinetics following COVID-19 vaccination. [PDF]

J R Soc Interface
Stocks D, Thomas A, Finn A, Danon L, Brooks-Pollock E.   +4 more
europepmc   +2 more sources

Deep time evolution of the Latitudinal Diversity Gradient: Insights from mechanistic models. [PDF]

PLoS One
Lorcery M, Husson L, Salles T, Lavergne S, Hagen O, Skeels A.   +5 more
europepmc   +1 more source